Proton Pump Inhibitor Treatment Has Little Effects on Secretion of Saliva in Patients with Proton Pump Inhibitor-Responsive Mild Reflux Esophagitis and Non-Erosive Reflux Disease
Proton Pump Inhibitor Treatment Has Little Effects on Secretion of Saliva in Patients with Proton Pump Inhibitor-Responsive Mild Reflux Esophagitis and Non-Erosive Reflux Disease
复制标题
质子泵抑制剂治疗对质子泵抑制剂反应性轻度反流性食管炎和非糜烂性反流病患者唾液分泌影响不大
DOI：
10.1159/000528086
复制
发表时间：
2022
期刊：
影响因子：
3.2
通讯作者：
Iwakiri Katsuhiko
中科院分区：
文献类型：
--
作者：
Hoshikawa Yoshimasa;Momma Eri;Hoshino Shintaro;Kawami Noriyuki;Kitasako Yuichi;Ikeda Masaomi;Iwakiri Katsuhiko
前言唾液的分泌是由酸通过食管唾液反射进入食管引起的，在食管的防御机制中起着至关重要的作用。胃食管反流病（GERD）患者分泌的唾液量减少。然而，质子泵抑制剂（PPI）对唾液分泌的影响很少报道。因此，本研究调查的体积和唾液pH值的变化后，停止PPI.Materials和MethodsWe回顾性地审查了连续患者的记录，以前诊断为轻度反流性食管炎（RE）或非糜烂性反流病（NERD）控制PPI（包括沃诺拉赞）进行唾液分泌试验之前和之后的2周停止PPI。的体积，pH值，和pH值后的唾液酸负荷（缓冲能力）进行了比较之前和之后停止PPI.Results32例（25 NERD，7轻度RE）。第二次唾液测试在第一次测试后的中位时间间隔为14个月[12.0-15.3]。停止PPI之前和之后分泌的唾液量没有观察到显着差异（4.0 mL之前[2.7-6.0]与4.0 mL之后[2.3-5.9]，p= 0.894）。PPI停药前后pH值或酸负荷后pH值变化无显著差异（pH值：停药前7.1±0.24 vs.停药后7.0±0.24，p= 0.1）。酸加载后的Δ pH：1.0前[0.8 - 1.2] vs. 1.0后[0.8 - 1.2]，p= 0.844）.结论PPI反应性轻度RE和NERD患者停止PPI治疗似乎不影响唾液的体积、pH值或缓冲能力。
IntroductionThe secretion of saliva, which is triggered by acid reflux into the esophagus via the esophagosalivary reflex, plays a crucial role in the defensive mechanisms of the esophagus. The volume of saliva secreted in patients with gastroesophageal reflux disease (GERD) is reduced. However, the effects of proton pump inhibitors (PPI) on the secretion of saliva have rarely been reported. Therefore, the present study investigated changes in the volume and pH of saliva after the cessation of PPI.Materials and MethodsWe retrospectively reviewed the records of consecutive patients previously diagnosed with mild reflux esophagitis (RE) or non-erosive reflux disease (NERD) controlled with PPI (including vonoprazan) who performed the salivary secretion test before and after a 2-week cessation of PPI. The volume, pH, and pH after acid loading (buffering capacity) of saliva were compared before and after the cessation of PPI.ResultsThirty-two patients (25 NERD, 7 mild RE) were included. The second saliva test was performed a median interval of 14 months [12.0–15.3] after the first test. No significant differences were observed in the volume of saliva secreted before and after the cessation of PPI (before 4.0 mL [2.7–6.0] vs. after 4.0 mL [2.3–5.9], p= 0.894). No significant differences were noted in pH or changes in pH after acid loading before and after the cessation of PPI (pH: before 7.1±0.24 vs. after 7.0±0.24, p= 0.1. Delta pH after acid loading: before 1.0 [0.8–1.2] vs. after 1.0 [0.8–1.2], p= 0.844).ConclusionThe cessation of PPI did not appear to affect the volume, pH, or buffering capacity of saliva in patients with PPI-responsive mild RE and NERD.
登录
查看更多内容
食管粘膜的愈合是否会改善食管粘膜下和唾液腺的功能？
影响因子：
5.2
作者：
J. Sarosiek
通讯作者：
J. Sarosiek
影响因子：
4.6
作者：
Kawar N;Park SG;Schwartz JL;Callahan N;Obrez A;Yang B;Chen Z;Adami GR
通讯作者：
Adami GR
影响因子：
3.5
作者：
Frazzoni, Marzio;Frazzoni, Leonardo;Savarino, Edoardo
通讯作者：
Savarino, Edoardo
使用手持式 pH 计进行简化和定量的唾液缓冲能力测试。
DOI：
--
发表时间：
2005
期刊：
American Journal of Dentistry 18(3)
影响因子：
--
作者：
Kitasako Y;Moritsuka M;Foxton RM;Ikeda M;Tagami J;Nomura S.
通讯作者：
Nomura S.
十二指肠溃疡患者的奥美拉唑治疗和唾液流量。
DOI：
--
发表时间：
2001
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Z. Namiot;J. Stasiewicz;M. Kralisz;M. Kozuszyńska;Adam R Markowski;F. K. Aljanaby;A. Kemona;J. Górski
通讯作者：
J. Górski