Synaptic tagging during memory allocation.
Synaptic tagging during memory allocation.
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DOI:
10.1038/nrn3667
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发表时间:
2014-03
影响因子:
34.7
通讯作者:
Silva, Alcino J.
中科院分区:
文献类型:
--
作者:
Rogerson, Thomas;Cai, Denise J.;Frank, Adam;Sano, Yoshitake;Shobe, Justin;Lopez-Aranda, Manuel F.;Silva, Alcino J.
There is now compelling evidence that the allocation of memory to specific neurons (neuronal allocation) and synapses (synaptic allocation) in a neurocircuit is not random and that instead specific mechanisms, such as increases in neuronal excitability and synaptic tagging and capture, determine the exact sites where memories are stored. We propose an integrated view of these processes, such that neuronal allocation, synaptic tagging and capture, spine clustering and metaplasticity reflect related aspects of memory allocation mechanisms. Importantly, the properties of these mechanisms suggest a set of rules that profoundly affect how memories are stored and recalled.
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DOI:
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发表时间:
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影响因子:
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