Synaptic tagging during memory allocation.

Synaptic tagging during memory allocation.
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DOI:
10.1038/nrn3667
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发表时间:
2014-03
影响因子:
34.7
通讯作者:
Silva, Alcino J.
Silva, Alcino J.
中科院分区:
医学1区
文献类型:
--
作者:
Rogerson, Thomas;Cai, Denise J.;Frank, Adam;Sano, Yoshitake;Shobe, Justin;Lopez-Aranda, Manuel F.;Silva, Alcino J.

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现在有令人信服的证据表明,在神经回路中,记忆分配给特定的神经元(神经元分配)和突触(突触分配)不是随机的,而是特定的机制,如神经元兴奋性的增加和突触标记和捕获,决定了记忆存储的确切位置。我们提出了一个综合的观点,这些过程,如神经元的分配,突触标记和捕获,脊柱集群和metaplasticity反映记忆分配机制的相关方面。重要的是,这些机制的特性表明了一套深刻影响记忆存储和回忆方式的规则。
There is now compelling evidence that the allocation of memory to specific neurons (neuronal allocation) and synapses (synaptic allocation) in a neurocircuit is not random and that instead specific mechanisms, such as increases in neuronal excitability and synaptic tagging and capture, determine the exact sites where memories are stored. We propose an integrated view of these processes, such that neuronal allocation, synaptic tagging and capture, spine clustering and metaplasticity reflect related aspects of memory allocation mechanisms. Importantly, the properties of these mechanisms suggest a set of rules that profoundly affect how memories are stored and recalled.
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