The 'emodin family' of fungal natural products-amalgamating a century of research with recent genomics-based advances.
The 'emodin family' of fungal natural products-amalgamating a century of research with recent genomics-based advances.
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DOI：
10.1039/d2np00040g
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发表时间：
2023-01-25
影响因子：
11.9
通讯作者：
中科院分区：
文献类型：
--
作者：
通过关键中间体大黄素及其相应的蒽酮，形成了一个非常大的生物合成连接真菌次生代谢物群。这类化合物包括蒽醌类，如大黄酚类和枝黄霉素类，大叶黄素类和锥酸类，二苯基醚类，二苯甲酮类，如二苯甲酮类，以及各种口山酮类，包括戊基化沙米山酮类，麦角色素类，隐孢子肽类和新石蒿素类。这些化合物表现出广泛的生物活性，因此已经在传统医学中使用了几个世纪，最近也引起了制药部门的兴趣。纺织品和化妆品等行业也对其感兴趣，因为它们被用作天然着色剂。这类化合物的多种生物合成途径和机制已被提出，随着新的生物合成方法的发展和新结果的出现，这些途径和机制被改变和更新。经过近100年的研究，本文旨在全面概述目前对这一重要家族的生物合成的了解，将早期的化学和生物合成研究与最近的基于遗传学和比较生物信息学的进展相结合。与蒽醌大黄素有关的真菌化合物是一个庞大而多样的家族。通过将这个家族视为一个整体，并结合我们的遗传和化学知识，我们对它们的生物合成起源有了详细的了解。
Covering: up to 2022 A very large group of biosynthetically linked fungal secondary metabolites are formed via the key intermediate emodin and its corresponding anthrone. The group includes anthraquinones such as chrysophanol and cladofulvin, the grisandienes geodin and trypacidin, the diphenyl ether pestheic acid, benzophenones such as monodictyphenone and various xanthones including the prenylated shamixanthones, the agnestins and dimeric xanthones such as the ergochromes, cryptosporioptides and neosartorin. Such compounds exhibit a wide range of bioactivities and as such have been utilised in traditional medicine for centuries, as well as garnering more recent interest from the pharmaceutical sector. Additional interest comes from industries such as textiles and cosmetics due to their use as natural colourants. A variety of biosynthetic routes and mechanisms have been proposed for this family of compounds, being altered and updated as new biosynthetic methods develop and new results emerge. After nearly 100 years of such research, this review aims to provide a comprehensive overview of what is currently known about the biosynthesis of this important family, amalgamating the early chemical and biosynthetic studies with the more recent genetics-based advances and comparative bioinformatics. A large and diverse family of fungal compounds are those related to the anthraquinone emodin. By viewing this family as a whole and combining our genetic and chemical understanding, we gain detailed insights into their biosynthetic origins.
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影响因子：
4.4
作者：
Chiang, Yi-Ming;Szewczyk, Edyta;Oakley, Berl R.
通讯作者：
Oakley, Berl R.
影响因子：
8.4
作者：
de Mattos-Shipley KMJ;Greco C;Heard DM;Hough G;Mulholland NP;Vincent JL;Micklefield J;Simpson TJ;Willis CL;Cox RJ;Bailey AM
通讯作者：
Bailey AM
影响因子：
4.3
作者：
Dhodary, Basanta;Schilg, Michele;Spiteller, Dieter
通讯作者：
Spiteller, Dieter
影响因子：
14.8
作者：
Bok, Jin Woo;Chiang, Yi-Ming;Szewczyk, Edyta;Reyes-Domingez, Yazmid;Davidson, Ashley D.;Sanchez, James F.;Lo, Hsien-Chun;Watanabe, Kenji;Strauss, Joseph;Oakley, Berl R.;Wang, Clay C. C.;Keller, Nancy P.
通讯作者：
Keller, Nancy P.
影响因子：
4.1
作者：
Boruta, Tomasz;Bizukojc, Marcin
通讯作者：
Bizukojc, Marcin