Obesity in children with poorly controlled asthma: Sex differences.
Obesity in children with poorly controlled asthma: Sex differences.
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DOI：
10.1002/ppul.22707
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发表时间：
2013-09
影响因子：
3.1
通讯作者：
Lima, John J.
中科院分区：
文献类型：
--
作者：
Lang, Jason E.;Holbrook, Janet T.;Wise, Robert A.;Dixon, Anne E.;Teague, W. Gerald;Wei, Christine Y.;Irvin, Charles G.;Shade, David;Lima, John J.
肥胖会增加哮喘的风险，并可能改变哮喘的严重程度。在成年人中，性似乎可以改变肥胖对哮喘的影响。在儿童中，性别对肥胖和哮喘严重程度之间关系的影响仍然不太清楚，特别是考虑到种族时。确定肥胖如何影响不同哮喘控制不良儿童队列的疾病特征，以及肥胖的影响是否因性别而改变。我们分析了306名6-17岁哮喘控制不佳的儿童，他们参加了一项为期6个月的评估兰索拉唑控制哮喘的试验。在二次分析中，我们确定了肥胖与症状严重程度、肺功能测定、加重风险、气道生物标志物、支气管反应性和气流感知之间的关系。我们使用多元线性回归和纵向混合效应模型来确定肥胖与性别是否相互作用影响哮喘的严重程度。无论性别如何，BMI>第95百分位数不影响哮喘控制、急性发作风险或气道生物标志物。性别改变了肥胖对肺功能的影响（性别 * 肥胖FEV1%，交互作用p值<.01，性别 * 肥胖FEV 1/FVC，交互作用p值=.03）。与非肥胖男性相比，肥胖男性的气流阻塞明显更严重，而在女性中，肥胖对气流阻塞没有影响。在女性中，肥胖与FEV 1和FVC显著增加以及气道反应性降低的趋势相关。肥胖不影响哮喘控制、气道标志物或疾病稳定性;然而，肥胖确实以性别依赖的方式影响肺功能。在男性中，肥胖与FEV 1/FVC降低相关，在女性中，肥胖与肺功能显著改善相关。
Obesity increases asthma risk, and may alter asthma severity. In adults, sex appears to modify the effect of obesity on asthma. Among children, the effect of sex on the relationship between obesity and asthma severity remains less clear, particularly when considering race. To determine how obesity affects disease characteristics in a diverse cohort of children with poorly controlled asthma, and if obesity effects are altered by sex. We analyzed 306 children between 6–17 years of age with poorly controlled asthma enrolled in a 6-month trial assessing lansoprazole for asthma control. In this secondary analysis, we determined associations between obesity and symptom severity, spirometry, exacerbation risk, airway biomarkers, bronchial reactivity and airflow perception. We used both a multivariate linear regression and longitudinal mixed-effect model to determine if obesity interacted with sex to affect asthma severity. Regardless of sex, BMI>95th percentile did not affect asthma control, exacerbation risk or airway biomarkers. Sex changed the effect of obesity on lung function (sex*obesity FEV1%, interaction p-value <.01, sex*obesity FEV1/FVC, interaction p-value=.03). Obese males had significantly worse airflow obstruction compared to non-obese males, while in females there was no obesity effect on airflow obstruction. In females, obesity was associated with significantly greater FEV1 and FVC, and a trend toward reduced airway reactivity. Obesity did not affect asthma control, airway markers or disease stability; however obesity did affect lung function in a sex-dependent manner. In males, obesity associated with reduced FEV1/FVC, and in females, obesity associated with substantially improved lung function.
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影响因子：
56.9
作者：
LAMPL, M;VELDHUIS, JD;JOHNSON, ML
通讯作者：
JOHNSON, ML
影响因子：
5.2
作者：
Li, AM;Chan, D;Fok, TF
通讯作者：
Fok, TF
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
影响因子：
5.7
作者：
Boezen, HA;Jansen, DF;Postma, DS
通讯作者：
Postma, DS
影响因子：
3.3
作者：
PAGTAKHAN, RD;BJELLAND, JC;TAUSSIG, LM
通讯作者：
TAUSSIG, LM