Circulating oxidized LDL and inflammation in extreme pediatric obesity.
Circulating oxidized LDL and inflammation in extreme pediatric obesity.
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DOI：
10.1038/oby.2011.21
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发表时间：
2011-07
期刊：
影响因子：
6.9
通讯作者：
Kelly, Aaron S.
中科院分区：
文献类型：
--
作者：
Norris, Anne L.;Steinberger, Julia;Steffen, Lyn M.;Metzig, Andrea M.;Schwarzenberg, Sarah Jane;Kelly, Aaron S.
氧化应激和炎症在极端的儿童肥胖症中尚未得到很好的描述。我们比较了极度肥胖(EO)儿童与正常体重(NW)和超重/肥胖(OW/OB)儿童循环氧化型低密度脂蛋白(OxLDL)、C反应蛋白(CRP)和白介素6(IL-6)的水平。对225例儿童青少年(年龄13.5±2.5岁；男孩55%)进行OxLDL、CRP、IL-6、体重指数(BMI)、血压、空腹血糖、胰岛素和血脂测定。根据不同性别和年龄的体重指数百分位数，参与者被分为三组：正常体重(NW)(第85位，n=127)、肥胖/肥胖(OW/OB，第85倍于第95百分位的1.2倍，n=)和高体重(≥为第95百分位的1.2倍，或体重指数≥为35 kg/m2，n=34)。使用ANCOVA比较了不同组之间的测量结果，并根据性别、年龄和种族进行了调整。体重指数组的血压、胰岛素和血脂均恶化(均为P<；0.0001)。氧化低密度脂蛋白(NW：40.8±9.0U/L，OW/OB：45.7±12.1U/L，EO：63.5±13.8U/L)和C反应蛋白(NW：0.5±1.0 mg/L，OW/OB：1.4±2.9 mg/L，EO：5.6±4.9 mg/L)在各体重指数组均显著升高(P均<0.01)。IL-6水平EO组(2.0±0.9pg/m L)显著高于OW/OB组(1.3±1.2pg/m L，p<0.001)和NW组(1.1±1.0pg/m L，P<0.0 1；0.0001)，但NW组与OW/OB组比较差异无统计学意义。与轻度肥胖和正常体重相比，极端儿童肥胖与较高水平的氧化应激和炎症水平有关，这表明早期心血管疾病和2型糖尿病的标志物已经存在于这一年轻人群中。
Oxidative stress and inflammation have not been well-characterized in extreme pediatric obesity. We compared levels of circulating oxidized LDL (oxLDL), C-reactive protein (CRP), and interleukin-6 (IL-6) in extremely obese (EO) children to normal weight (NW) and overweight/obese (OW/OB) children. OxLDL, CRP, IL-6, body mass index (BMI), blood pressure, and fasting glucose, insulin, and lipids were obtained in 225 children and adolescents (age 13.5 ± 2.5 years; boys 55%). Participants were classified into three groups based on gender- and age-specific BMI percentile: NW (<85th, n = 127), OW/OB (85th-<1.2 times the 95th percentile, n = 64) and EO (≥1.2 times the 95th percentile or BMI ≥35 kg/m2, n = 34). Measures were compared across groups using ANCOVA, adjusted for gender, age, and race. Blood pressure, insulin, and lipids worsened across BMI groups (all p<0.0001). OxLDL (NW: 40.8 ± 9.0 U/L, OW/OB: 45.7 ± 12.1 U/L, EO: 63.5 ± 13.8 U/L) and CRP (NW: 0.5 ± 1.0 mg/L, OW/OB: 1.4 ± 2.9 mg/L, EO: 5.6 ± 4.9 mg/L) increased significantly across BMI groups (all groups differed with p<0.01). IL-6 was significantly higher in EO (2.0 ± 0.9 pg/mL) compared to OW/OB (1.3 ± 1.2 pg/mL, p<0.001) and NW (1.1 ± 1.0 pg/mL, p<0.0001) but was not different between NW and OW/OB. Extreme pediatric obesity, compared to milder forms of adiposity and normal weight, is associated with higher levels of oxidative stress and inflammation, suggesting that markers of early cardiovascular disease and type 2 diabetes mellitus are already present in this young population.
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