Periodic maternal deprivation may modulate offspring anxiety-like behavior through mechanisms involving neuroplasticity in the amygdala.
Periodic maternal deprivation may modulate offspring anxiety-like behavior through mechanisms involving neuroplasticity in the amygdala.
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DOI：
10.1016/j.brainresbull.2013.12.005
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发表时间：
2014-02
影响因子：
3.8
通讯作者：
Donaldson ST
中科院分区：
文献类型：
--
作者：
Berman AK;Lott RB;Donaldson ST
孕产妇护理已被证明会影响行为和内分泌系统的发育。在大鼠中，周期性母性剥夺（PMD）是一种早期生命压力源，通过促进应激母鼠中更多针对幼仔的行为，直接影响母性护理。为了进一步评估 PMD 的质量可能会改善特质焦虑动物的长期焦虑影响，我们对表型为高焦虑 (HAn) 和低焦虑 (LAn) 的母鼠整个哺乳期（出生后第 5、16、21 天）的行为进行了编码。我们使用高架十字迷宫 (EPM) 评估了雄性后代的焦虑样行为，重点关注开臂时间百分比 (%OA) 和进入 OA 的潜伏期 (OA LAT) 作为焦虑样行为的衡量标准。最后，我们检查了代表性雄性幼崽的大脑，以确定与压力相关的蛋白脑源性神经营养因子（BDNF）是否可能在杏仁核中表现出持续的变化。相对于指定为 LAn 的母鼠，表型为 HAn 的母鼠具有较低的 %OA 时间和较长的 OA LAT。在 PMD 期间，与 LAn 水坝相比，HAn 水坝在 PND 5 和 16 上舔梳理行为 (L/G) 的发生率更高，并且有更多针对幼崽的行为。此外，成年后，HAn 雄性后代表现出比其母系更少的焦虑特征，并且相对于 LAN 而言，OA 时间百分比和 OA 条目百分比更高。 HAn 后代的杏仁核中 BDNF 免疫反应细胞明显多于 LAn。这些发现结合起来表明，轻度应激源 PMD 可能通过影响 HAn 母鼠的 L/G 活性和改变杏仁核中的应激相关蛋白来改变后代的焦虑样行为。
Maternal care has been shown to affect the development of behavioral and endocrine systems. In rats, periodic maternal deprivation (PMD) serves as an early life stressor that directly influences maternal care by promoting more pup-directed behaviors in stressed dams. To further assess the qualities of PMD that may ameliorate long-term anxiety effects in trait anxiety animals, we coded behaviors across lactation (postnatal day (PND) 5, 16, 21) in dams phenotyped as high (HAn) and low-anxiety (LAn). We assessed anxiety-like behavior in male offspring using the elevated plus maze (EPM), focusing on percent open arm (%OA) time and latency to enter OA (OA LAT) as a measure of anxiety-like behavior. Finally, we examined the brains of representative male pups to determine if the stress-related protein brain-derived neurotrophic factor (BDNF) might show persistent changes in the amygdala. Dams phenotyped as HAn had lower %OA time and longer OA LAT relative to dams designated as LAn. During PMD, HAn dams had higher incidences of lick-grooming (L/G) and more pup-directed behaviors on PND 5 and 16 compared to LAn dams. Further, as adults, HAn male offspring exhibited less anxiety traits than their maternal line with greater %OA time and %OA entries relative to LAn. HAn offspring showed markedly more BDNF immunoreacted cells in the amygdala than LAn. The combination of these findings suggests that the mild stressor, PMD alters anxiety-like behavior in offspring likely by influencing HAn dams’ L/G activity and altering stress related proteins in the amygdala.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
8.2
作者：
Cirulli, F;Berry, A;Alleva, E
通讯作者：
Alleva, E
影响因子：
8.2
作者：
Pryce, CR;Feldon, J
通讯作者：
Feldon, J
影响因子：
2.5
作者：
Kohl, Z;Kuhn, HG;Kempermann, G
通讯作者：
Kempermann, G
影响因子：
5.3
作者：
Schafe, GE;LeDoux, JE
通讯作者：
LeDoux, JE