Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate.
Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate.
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DOI：
10.1001/archpsyc.65.9.1008
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发表时间：
2008-09
影响因子：
--
通讯作者：
Thaker, Gunvant K.
中科院分区：
文献类型：
--
作者：
Hong, L. Elliot;Summerfelt, Ann;Mitchell, Braxton D.;McMahon, Robert P.;Wonodi, Ikwunga;Buchanan, Robert W.;Thaker, Gunvant K.
听觉感觉门控缺陷被认为是精神分裂症的主要内表型。然而，通常使用的感觉门控指数P50在精神分裂症患者家庭中的遗传率较低，这引发了人们对其在遗传学研究中的实用性的质疑。我们假设感觉门控缺陷可能发生在特定的神经元振荡频率中，该频率反映了感觉门控潜在的生物学过程。特定频率的感觉门控可能没有P50反应那么复杂，因此更接近直接的遗传效应，因此是更有效的内表型。比较频率特异性振荡反应(S)门控与P50门控；比较两者的遗传力。我们在精神分裂症患者、他们的亲属和社区对照中探索了基于单次试验的振荡门控反应。门诊部。精神分裂症患者(n=102)、其一级亲属(n=74)和社区对照组(n=70)。没有。频率特定振荡反应的门控，P50波的门控，以及它们的遗传力估计。阿尔法西塔频段反应的门控显著地将对照组与精神分裂症患者(p<；0.001)及其一级亲属(p=0.039-0.009)分开。α-theta带门控的遗传度估计为0.49-0.83，至少比P50遗传度估计高4倍。在配对点击范式中，α-theta频率振荡信号的选通与精神分裂症的相关性更强，并且与传统的P50选通相比具有显著更高的遗传率。这一方法可能更适合于精神分裂症门控缺陷的遗传学研究。
The auditory sensory gating deficit has been considered a leading endophenotype in schizophrenia. However, the commonly used index of sensory gating, P50, has low heritability in families of people with schizophrenia, raising questions about its utility in genetic studies. We hypothesized that the sensory gating deficit may occur in a specific neuronal oscillatory frequency that reflects the underlying biological process of sensory gating. Frequency-specific sensory gating may be less complex than the P50 response, and therefore closer to direct genetic effects and thus a more valid endophenotype. To compare gating of frequency-specific oscillatory response(s) with gating of P50; to compare their heritabilities. We explored single-trial based oscillatory gating responses in people with schizophrenia, their relatives, and community controls. Outpatient clinics. People with schizophrenia (n=102), their first-degree relatives (n=74), and community controls (n=70). None. Gating of frequency-specific oscillatory responses, gating of the P50 wave, and their heritability estimates. Gating of the alpha-theta band responses significantly separated controls from people with schizophrenia (p<0.001) and their first-degree relatives (p=0.039 - 0.009). The heritability of alpha-theta band gating was estimated to be 0.49–0.83 and was at least 4-fold higher than the P50 heritability estimate. Gating of the alpha-theta frequency oscillatory signal in the paired-click paradigm is more strongly associated with schizophrenia and has significantly higher heritability compared to the traditional P50 gating. This measure may be better suited for genetic studies of the gating deficit in schizophrenia.
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影响因子：
1.6
作者：
ADLER, JD;SIFFT, J
通讯作者：
SIFFT, J
影响因子：
2
作者：
Clementz, BA;Blumenfeld, LD
通讯作者：
Blumenfeld, LD
影响因子：
4.5
作者：
Anokhin, Andrey P.;Vedeniapin, Andrei B.;Boutros, Nashaat N.
通讯作者：
Boutros, Nashaat N.
影响因子：
--
作者：
Cannon, TD;Kaprio, J;Koskenvuo, M
通讯作者：
Koskenvuo, M
影响因子：
17.7
作者：
Adler, LE;Olincy, A;Freedman, R
通讯作者：
Freedman, R