Emerging targets in lipid-based therapy.
Emerging targets in lipid-based therapy.
复制标题
DOI：
10.1016/j.bcp.2012.11.028
复制
发表时间：
2013-03-01
影响因子：
5.8
通讯作者：
Honn KV
中科院分区：
文献类型：
--
作者：
Tucker SC;Honn KV
在临床上使用的三尖杉酯碱和NSAIDS已证明，脂质介质及其相关的途径，使有吸引力的治疗目标。当考虑涉及脂质途径的治疗时，几种基本药物会浮现在脑海中。有导致脂质底物代谢的酶和辅助蛋白，通过饮食或脂肪酶的作用提供，随后的脂质产物，最后是脂质传感器或受体。有大量证据表明，分子沿着这一脂质连续体可以作为预后和诊断指标，实际上是可行的治疗目标。此外，脂质本身可用作治疗剂。尽管如此，关于“生物标志物”的对话通常不包括脂质的提及，尽管这正在迅速改变。总的来说，这些药物在从癌症到早产的各种疾病过程中的各自作用越来越受到重视，并且在脂质领域数十年的基础工作后得到了应有的重视。通过相关的例子，疾病的过程，导致功能障碍沿着脂质连续体，以及脂质治疗和新兴技术的例子，这篇评论是为了激发进一步的阅读和发现。
The use of prostaglandins and NSAIDS in the clinic has proven that lipid mediators and their associated pathways make attractive therapeutic targets. When contemplating therapies involving lipid pathways, several basic agents come to mind. There are the enzymes and accessory proteins that lead to the metabolism of lipid substrates, provided through diet or through actions of lipases, the subsequent lipid products, and finally the lipid sensors or receptors. There is abundant evidence that molecules along this lipid continuum can serve as prognostic and diagnostic indicators and are in fact viable therapeutic targets. Furthermore, lipids themselves can be used as therapeutics. Despite this, the vernacular dialog pertaining to “biomarkers” does not routinely include mention of lipids, though this is rapidly changing. Collectively these agents are becoming more appreciated for their respective roles in diverse disease processes from cancer to preterm labor and are receiving their due appreciation after decades of ground work in the lipid field. By relating examples of disease processes that result from dysfunction along the lipid continuum, as well as examples of lipid therapies and emerging technologies, this review is meant to inspire further reading and discovery.
登录
查看更多内容
影响因子：
44.1
作者：
通讯作者：
--
通过质谱法对组织中脂质生物化学的MALDI成像。
影响因子：
62.1
作者：
Berry, Karin A. Zemski;Hankin, Joseph A.;Barkley, Robert M.;Spraggins, Jeffrey M.;Caprioli, Richard M.;Murphy, Robert C.
通讯作者：
Murphy, Robert C.
影响因子：
--
作者：
Agarwal, Sandeep K.
通讯作者：
Agarwal, Sandeep K.
影响因子：
9.7
作者：
Benelli, Roberto;Vene, Roberta;Ferrari, Nicoletta
通讯作者：
Ferrari, Nicoletta
影响因子：
2.9
作者：
BAUMANN, J;BRUCHHAUSEN, FV;WURM, G
通讯作者：
WURM, G