Vitamin K deficiency is associated with incident knee osteoarthritis.
Vitamin K deficiency is associated with incident knee osteoarthritis.
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DOI：
10.1016/j.amjmed.2012.10.011
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发表时间：
2013-03
影响因子：
5.9
通讯作者：
Neogi, Tuhina
中科院分区：
文献类型：
--
作者：
Misra, Devyani;Booth, Sarah L.;Tolstykh, Irina;Felson, David T.;Nevitt, Michael C.;Lewis, Cora E.;Torner, James;Neogi, Tuhina
骨关节炎是最常见的关节炎形式，膝骨关节炎是美国老年人下肢残疾的主要原因。没有可用的治疗方法来预防骨关节炎的结构性病理学。由于维生素 K 在调节骨骼矿化方面的作用，它有可能成为骨关节炎的预防选择。因此，我们研究了维生素 K 与新发放射学膝骨关节炎和磁共振成像 (MRI) 上早期骨关节炎变化的关系。多中心骨关节炎 (MOST) 研究的受试者在基线和 30 个月后进行了膝关节 X 光检查和 MRI 扫描，并在基线时测量了血浆叶绿醌（维生素 K）。我们使用对数二项式回归和广义估计方程，调整潜在的混杂因素，分别检查了亚临床维生素 K 缺乏与放射学膝骨关节炎和基于 MRI 的软骨病变和骨赘的关系。在 1180 名参与者中（62% 为女性，平均年龄 62 ± 8 岁，平均体重指数 30.1 ± 5.1 kg/m2），亚临床维生素 K 缺乏与放射学膝骨关节炎（风险比 [RR] 1.56；95% 置信区间 [CI]，1.08–2.25）和软骨病变（RR 2.39；95% CI， 1.05–5.40）与无缺陷相比，但骨赘则不然（RR 2.35；95% CI，0.54–10.13）。亚临床维生素 K 缺乏的受试者比双膝均更容易患上骨关节炎（RR 1.33；95% CI，1.01-1.75；RR 2.12；95% CI，1.06-4.24）。在第一项此类纵向研究中，亚临床维生素 K 缺乏与发生放射学膝骨关节炎和基于 MRI 的软骨病变的风险增加相关。鉴于维生素 K 对骨关节炎的治疗/预防潜力，有必要对其进行进一步研究。
Osteoarthritis is the most common form of arthritis, with knee osteoarthritis being the leading cause of lower extremity disability among older adults in the US. There are no treatments available to prevent the structural pathology of osteoarthritis. Because of vitamin K’s role in regulating skeletal mineralization, it has potential to be a preventative option for osteoarthritis. We therefore examined the relation of vitamin K to new-onset radiographic knee osteoarthritis and early osteoarthritis changes on magnetic resonance imaging (MRI). Subjects from the Multicenter Osteoarthritis (MOST) Study had knee radiographs and MRI scans obtained at baseline and 30 months later, and plasma phylloquinone (vitamin K) measured at baseline. We examined the relationship of subclinical vitamin K deficiency to incident radiographic knee osteoarthritis and MRI-based cartilage lesions and osteophytes, respectively, using log binomial regression with generalized estimating equations, adjusting for potential confounders. Among 1180 participants (62% women, mean age 62 ± 8 years, mean body mass index 30.1 ± 5.1 kg/m2), subclinical vitamin K deficiency was associated with incident radiographic knee osteoarthritis (risk ratio [RR] 1.56; 95% confidence interval [CI], 1.08–2.25) and cartilage lesions (RR 2.39; 95% CI, 1.05–5.40) compared with no deficiency, but not with osteophytes (RR 2.35; 95% CI, 0.54–10.13). Subclinically vitamin K-deficient subjects were more likely to develop osteoarthritis in one or both knees than neither knee (RR 1.33; 95% CI, 1.01–1.75 and RR 2.12; 95% CI, 1.06-4.24, respectively). In the first such longitudinal study, subclinical vitamin K deficiency was associated with increased risk of developing radiographic knee osteoarthritis and MRI-based cartilage lesions. Further study of vitamin K is warranted given its therapeutic/prophylactic potential for osteoarthritis.
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影响因子：
27.4
作者：
Neogi T;Felson DT;Sarno R;Booth SL
通讯作者：
Booth SL
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
4.2
作者：
Booth, SL;Suttie, JW
通讯作者：
Suttie, JW
影响因子：
1.7
作者：
Oka, Hiroyuki;Akune, Toru;Yoshimura, Noriko
通讯作者：
Yoshimura, Noriko
影响因子：
--
作者：
Loeser, RF;Varnum, BC;Wallin, R
通讯作者：
Wallin, R