Language network lateralization is reflected throughout the macroscale functional organization of cortex.
Language network lateralization is reflected throughout the macroscale functional organization of cortex.
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DOI：
10.1038/s41467-023-39131-y
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发表时间：
2023-06-09
影响因子：
16.6
通讯作者：
Holmes, Avram J.
中科院分区：
文献类型：
--
作者：
Labache, Loic;Ge, Tian;Yeo, B. T. Thomas;Holmes, Avram J.
半球特化是人脑组织的基本特征。然而，目前还不清楚在多大程度上，特定的认知过程的偏侧化可能是明显的整个广泛的功能架构的皮层。虽然大多数人表现出左半球语言优势，但也有相当一部分人表现出反向侧化。使用人类连接组项目的双胞胎和家庭数据，我们提供的证据表明，非典型语言优势与皮质组织的全球变化有关。具有非典型语言组织的个体在宏观功能梯度上表现出相应的半球差异，这些梯度将离散的大规模网络沿着一个连续的频谱，从单峰延伸到联想领域。分析表明，语言偏侧化和梯度不对称性部分是由遗传因素驱动的。这些发现铺平了道路，更深入地了解的起源和关系，连接人口水平的变化，大脑半球的专业化和全球性能的皮质组织。半球特化是人脑组织的一个基本方面。在这里，作者证明了语言偏侧化是可遗传的，并且在大脑皮层的广泛功能结构中是明显的。
Hemispheric specialization is a fundamental feature of human brain organization. However, it is not yet clear to what extent the lateralization of specific cognitive processes may be evident throughout the broad functional architecture of cortex. While the majority of people exhibit left-hemispheric language dominance, a substantial minority of the population shows reverse lateralization. Using twin and family data from the Human Connectome Project, we provide evidence that atypical language dominance is associated with global shifts in cortical organization. Individuals with atypical language organization exhibit corresponding hemispheric differences in the macroscale functional gradients that situate discrete large-scale networks along a continuous spectrum, extending from unimodal through association territories. Analyses reveal that both language lateralization and gradient asymmetries are, in part, driven by genetic factors. These findings pave the way for a deeper understanding of the origins and relationships linking population-level variability in hemispheric specialization and global properties of cortical organization. Hemispheric specialization is a fundamental aspect of human brain organization. Here, the authors demonstrate that language lateralization is heritable and evident throughout the broad functional architecture of cortex.
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影响因子：
5.7
作者：
Binder JR;Gross WL;Allendorfer JB;Bonilha L;Chapin J;Edwards JC;Grabowski TJ;Langfitt JT;Loring DW;Lowe MJ;Koenig K;Morgan PS;Ojemann JG;Rorden C;Szaflarski JP;Tivarus ME;Weaver KE
通讯作者：
Weaver KE
影响因子：
2.5
作者：
Carrion-Castillo, Amaia;Van der Haegen, Lise;Francks, Clyde
通讯作者：
Francks, Clyde
Vav-iCre介导的Pig-a条件敲除小鼠模型：稳定的GPI缺陷和轻度溶血
影响因子：
10.9
作者：
Chen Y;Liu H;Zeng L;Li L;Lu D;Liu Z;Fu R
通讯作者：
Fu R
DOI：
10.1016/j.yebeh.2010.08.004
发表时间：
2011-02
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Binder JR
通讯作者：
Binder JR
DOI：
10.1126/science.1230531
发表时间：
2013-06-14
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bishop DV
通讯作者：
Bishop DV