Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice.
Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice.
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DOI：
10.1016/j.bbr.2012.08.051
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发表时间：
2013-01-15
影响因子：
2.7
通讯作者：
Brodkin, Edward S.
中科院分区：
文献类型：
--
作者：
Fairless, Andrew H.;Katz, Julia M.;Vijayvargiya, Neha;Dow, Holly C.;Kreibich, Arati Sadalge;Berrettini, Wade H.;Abel, Ted;Brodkin, Edward S.
BALB/cJ和C57 BL/6 J近交系小鼠品系已被提出分别作为低水平和高水平社交性（寻求社会互动的倾向）的有用模型，主要基于~30日龄小鼠在社会接近测试（SAT）中的行为。在SAT中，在新的环境中测量测试小鼠对不熟悉的刺激小鼠的接近和嗅闻行为。然而，目前还不清楚这些结果是否适用于熟悉的环境与熟悉的社会伙伴，如与窝在一个家庭笼环境。我们假设，C57 BL/6 J小鼠将显示出更高水平的社会行为比BALB/cJ小鼠在家庭笼环境中，特别是在30日龄。我们测量了主动和被动的社会行为，在家庭笼对BALB/cJ或C57 BL/6 J同窝仔在年龄30，41，和69天。菌株在积极的社会行为方面没有明显差异。在30天时，C57 BL/6 J小鼠比BALB/cJ小鼠更被动地社交，并且C57 BL/6 J小鼠的被动社交行为水平在69天时下降到BALB/cJ小鼠的水平。30日龄时被动社会行为的差异主要归因于蜷缩行为的差异。这些结果表明，不同的测试条件（SAT条件与饲养笼条件）在不同类型的行为（分别为接近/嗅探与蜷缩行为）中引起应变差异。评估更自然的社会互动，在熟悉的家庭笼环境与熟悉的同窝将提供一个有用的组成部分，全面评估社会行为的小鼠模型相关的自闭症。
BALB/cJ and C57BL/6J inbred mouse strains have been proposed as useful models of low and high levels of sociability (tendency to seek social interaction), respectively, based primarily on behaviors of ~30-day-old mice in the Social Approach Test (SAT). In the SAT, approach and sniffing behaviors of a test mouse toward an unfamiliar stimulus mouse are measured in a novel environment. However, it is unclear whether such results generalize to a familiar environment with a familiar social partner, such as with a littermate in a home cage environment. We hypothesized that C57BL/6J mice would show higher levels of social behaviors than BALB/cJ mice in the home cage environment, particularly at 30 days-of-age. We measured active and passive social behaviors in home cages by pairs of BALB/cJ or C57BL/6J littermates at ages 30, 41, and 69 days. The strains did not differ robustly in their active social behaviors. C57BL/6J mice were more passively social than BALB/cJ mice at 30 days, and C57BL/6J levels of passive social behaviors declined to BALB/cJ levels by 69 days. The differences in passive social behaviors at 30 days-of-age were primarily attributable to differences in huddling. These results indicate that different test conditions (SAT conditions vs. home cage conditions) elicit strain differences in distinct types of behaviors (approach/sniffing vs. huddling behaviors, respectively). Assessment of the more naturalistic social interactions in the familiar home cage environment with a familiar littermate will provide a useful component of a comprehensive assessment of social behaviors in mouse models relevant to autism.
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DOI：
10.1002/ar.21318
发表时间：
2011-10
影响因子：
2
作者：
Fairless, Andrew H.;Shah, Rhia Y.;Guthrie, Ashley J.;Li, Hongzhe;Brodkin, Edward S.
通讯作者：
Brodkin, Edward S.
影响因子：
--
作者：
Jones, Warren;Carr, Katelin;Klin, Ami
通讯作者：
Klin, Ami
影响因子：
2.7
作者：
Dahlhaus, Regina;El-Husseini, Alaa
通讯作者：
El-Husseini, Alaa
影响因子：
3.8
作者：
Jacome, Luis F.;Burket, Jessica A.;Deutsch, Stephen I.
通讯作者：
Deutsch, Stephen I.
影响因子：
4.7
作者：
Chadman, Kathryn K.;Gong, Shiaoching;Crawley, Jacqueline N.
通讯作者：
Crawley, Jacqueline N.