Deconstructing sociability, an autism-relevant phenotype, in mouse models.
Deconstructing sociability, an autism-relevant phenotype, in mouse models.
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DOI：
10.1002/ar.21318
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发表时间：
2011-10
影响因子：
2
通讯作者：
Brodkin, Edward S.
中科院分区：
文献类型：
--
作者：
Fairless, Andrew H.;Shah, Rhia Y.;Guthrie, Ashley J.;Li, Hongzhe;Brodkin, Edward S.
社交能力降低是自闭症谱系障碍（ASD）的核心特征，并且高度致残，知之甚少，治疗难治。为了阐明社交能力降低的生物学基础，多个实验室正在开发ASD相关的小鼠模型，其中社交能力通常使用社会选择测试进行评估。然而，该测试中包含的各种测量有时支持不同的结论。具体而言，“测试”小鼠在受限的“刺激”小鼠附近花费的时间的测量（室分数）有时支持与测试小鼠嗅含刺激小鼠的圆筒的时间的测量（圆筒分数）不同的结论。这就提出了一个问题，即哪种类型的测量方法最适合评估社交能力。我们评估了重测信度和生态效度的腔和缸的分数。与分庭分数相比，气缸分数测试和复试测量之间的相关性较高，气缸分数显示出较高的相关性，在社会交往中花费的时间在一个更自然的测试阶段。这表明圆柱体分数是小鼠模型中社交性的更可靠和有效的测量。圆柱体分数比腔室分数报告得更少，这可能是因为很少有工作被做来建立用于测量前者的自动化软件系统。在这项研究中，我们发现一个特定的自动化软件系统在测量圆柱体分数时至少表现得和人类评分员一样好。我们的数据表明，气缸的分数是更可靠和有效的比商会的分数，前者可以非常准确地测量ASD相关模型中使用自动视频分析系统。
Reduced sociability is a core feature of autism spectrum disorders (ASD) and is highly disabling, poorly understood, and treatment refractory. To elucidate the biological basis of reduced sociability, multiple laboratories are developing ASD-relevant mouse models, in which sociability is commonly assessed using the Social Choice Test. However, various measurements included in that test sometimes support different conclusions. Specifically, measurements of time the “test” mouse spends near a confined “stimulus” mouse (chamber scores) sometimes support different conclusions from measurements of time the test mouse sniffs the cylinder containing the stimulus mouse (cylinder scores). This raises the question of which type of measurements are best for assessing sociability. We assessed the test-retest reliability and ecological validity of chamber and cylinder scores. Compared with chamber scores, cylinder scores showed higher correlations between test and retest measurements, and cylinder scores showed higher correlations with time spent in social interaction in a more naturalistic phase of the test. This suggests that cylinder scores are more reliable and valid measures of sociability in mouse models. Cylinder scores are reported less commonly than chamber scores, perhaps because little work has been done to establish automated software systems for measuring the former. In this study, we found that a particular automated software system performed at least as well as human raters at measuring cylinder scores. Our data indicate that cylinder scores are more reliable and valid than chamber scores, and that the former can be measured very accurately using an automated video analysis system in ASD-relevant models.
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DOI：
10.1098/rstb.2002.1209
发表时间：
2003-02-28
影响因子：
6.3
作者：
Hill, EL;Frith, U
通讯作者：
Frith, U
影响因子：
2.5
作者：
McFarlane, H. G.;Kusek, G. K.;Crawley, J. N.
通讯作者：
Crawley, J. N.
影响因子：
2.5
作者：
Nadler, JJ;Moy, SS;Crawley, JN
通讯作者：
Crawley, JN
影响因子：
3.5
作者：
Moretti, P;Bouwknecht, JA;Zoghbi, HY
通讯作者：
Zoghbi, HY
影响因子：
2.7
作者：
Pobbe, Roger L. H.;Pearson, Brandon L.;Defensor, Erwin B.;Bolivar, Valerie J.;Blanchard, D. Caroline;Blanchard, Robert J.
通讯作者：
Blanchard, Robert J.