Ecclesiastes, cardiac arrest, and the electrocardiogram.
Ecclesiastes, cardiac arrest, and the electrocardiogram.
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传道书、心脏骤停和心电图。
DOI：
10.1111/j.1540-8159.2005.00162.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Walcott,GregoryP
中科院分区：
文献类型：
--
作者：
Ideker,RaymondE;Huang,Jian;Walcott,GregoryP
1930年，威格斯用高速摄影技术显示心脏在心室颤动（VF）持续的最初几十分钟内经历了不同的阶段。最近，很明显，在心脏经过这些阶段的不同时间，心脏骤停后复苏的最佳治疗方法是不同的。Weisfeldt和Becker提出了心肺复苏的三个阶段模型，以反映复苏生理学的这种时间敏感性进展。他们称心室颤动的前4分钟为电相，此时最好的治疗方法是立即除颤。他们把大约4分钟到10分钟的心室颤动称为循环阶段，在这个阶段，目前最好的治疗方法可能是将除颤延迟1-3分钟，同时进行胸外按压和通气以向心脏提供氧气。他们将大约10分钟VF后的这段时间标记为代谢阶段，在此期间，全身缺血事件和再灌注引起的组织损伤诱导循环代谢因子，除了局部缺血的影响外，还造成额外的损伤。Weisfeldt和Becker回顾了体外循环和体外冷却在这一阶段可能有益的证据，但肾上腺素在循环阶段可能有益，在代谢阶段可能有害。2-7因此，在复苏过程中开始治疗之前，了解VF的持续时间是很重要的。然而，当第一反应者到达现场时，他们通常不知道VF已经存在了多久。传道书1:9说：“…日光之下并没有新事。”这一说法适用于Callihan等人发表在最新一期《PACE》上的文章，这是许多分析体表的出版物中最新的一篇
In 1930, Wiggers used high-speed cinematography to show that the heart passes through different stages during the first few tens of minutes as ventricular fibrillation (VF) continues. 1 Recently, it has become apparent that the best treatment during resuscitation following cardiac arrest is different at different times as the heart passes through these stages. Weisfeldt and Becker have proposed a three-phased model of cardiopulmonary resuscitation to reflect this time-sensitive progression of resuscitation physiology. 2 They call the first 4 minutes of VF the electrical phase in which the best treatment is immediate defibrillation. They call the period from approximately 4 minutes to approximately 10 minutes of VF the circulatory phase in which the best current therapy may be to delay defibrillation for 1–3 minutes, while chest compressions and ventilation are performed to provide oxygen to the heart. They label the period after approximately 10 minutes of VF the metabolic phase during which tissue injuries from global ischemic events and from reperfusion induces circulating metabolic factors that cause additional injury in addition to the effects of local ischemia. Weisfeldt and Becker review the evidence that cardiopulmonary bypass and external cooling may be beneficial during this phase but that epinephrine, which may be beneficial during the circulatory phase, may be detrimental in the metabolic phase. 2–7 Therefore, it is important to know the duration of VF before initiating the therapy during resuscitation. However, first responders typically do not know how long VF has been present when they arrive at the scene.Ecclesiastes 1: 9 states “... there is no new thing under the sun.” This statement applies to the article in the current issue of PACE by Callihan et al., 8 which is the most recent of a number of publications that have analyzed the body surface
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Na+-K+ 泵体液抑制剂在某些实验性高血压模型中的演示
影响因子：
8.3
作者：
S. Huot;J. Buggy;D. Clough;F. Haddy
通讯作者：
F. Haddy
脐带和母体血清以及胎盘提取物中的地高辛免疫反应性。
影响因子：
2.8
作者：
E. Diamandis;A. Papanastasiou;S. Soldin
通讯作者：
S. Soldin
使用高效液相色谱法测定人血浆和尿液中的内源性 Na+,K+-ATP 酶抑制剂
影响因子：
3.5
作者：
M. Crabos;Irving W. Wainer;J. Cloix
通讯作者：
J. Cloix
血浆洋地黄样因子随着盐负荷的增加而增加。
DOI：
10.1056/nejm198312083092316
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Gault;S. Vasdev;L. Longerich;P. Fernandez;V. Prabhakaran;M. Dawe;C. Maillet
通讯作者：
C. Maillet
影响因子：
5.8
作者：
GRAVES, SW;WILLIAMS, GH
通讯作者：
WILLIAMS, GH