Biological Timing and Neurodevelopmental Disorders: A Role for Circadian Dysfunction in Autism Spectrum Disorders.
Biological Timing and Neurodevelopmental Disorders: A Role for Circadian Dysfunction in Autism Spectrum Disorders.
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DOI：
10.3389/fnins.2021.642745
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发表时间：
2021
影响因子：
4.3
通讯作者：
Cao R
中科院分区：
文献类型：
--
作者：
Lorsung E;Karthikeyan R;Cao R
自闭症谱系障碍（ASD）是一系列神经发育障碍，其特征是社会互动和沟通受损，以及刻板和重复行为。ASD影响近2%的美国儿童人口，近年来全球患病率急剧增加。其病因尚不清楚，但ASD被认为是由内在和外在因素共同引起的。昼夜节律是由内源性生物钟驱动的昼夜节律，存在于多种生理过程中。越来越多的基础和临床研究表明，ASD及其发病机制可能与昼夜节律计时系统功能障碍有关。在这里，我们回顾了实验和临床研究中将昼夜节律功能障碍与ASD联系起来的发现。我们首先介绍了昼夜节律系统和ASD的组织。接下来，我们回顾了ASD患者的昼夜节律的生理指标，包括睡眠-觉醒周期、褪黑激素、皮质醇和5-羟色胺。最后，我们回顾了流行病学、人类遗传学和生物化学方面的证据，这些证据表明昼夜节律调节与ASD发病机制之间存在潜在联系。总之，我们建议，了解正常和异常的神经发育过程中的生物钟的功能的重要性，可以提供一个新的视角来解决ASD，和ASD个体的临床治疗应包括一个综合的方法，考虑在身体，心理和社会过程中的日常节奏的动态。
Autism spectrum disorders (ASDs) are a spectrum of neurodevelopmental disorders characterized by impaired social interaction and communication, as well as stereotyped and repetitive behaviors. ASDs affect nearly 2% of the United States child population and the worldwide prevalence has dramatically increased in recent years. The etiology is not clear but ASD is thought to be caused by a combination of intrinsic and extrinsic factors. Circadian rhythms are the ∼24 h rhythms driven by the endogenous biological clock, and they are found in a variety of physiological processes. Growing evidence from basic and clinical studies suggest that the dysfunction of the circadian timing system may be associated with ASD and its pathogenesis. Here we review the findings that link circadian dysfunctions to ASD in both experimental and clinical studies. We first introduce the organization of the circadian system and ASD. Next, we review physiological indicators of circadian rhythms that are found disrupted in ASD individuals, including sleep–wake cycles, melatonin, cortisol, and serotonin. Finally, we review evidence in epidemiology, human genetics, and biochemistry that indicates underlying associations between circadian regulation and the pathogenesis of ASD. In conclusion, we propose that understanding the functional importance of the circadian clock in normal and aberrant neurodevelopmental processes may provide a novel perspective to tackle ASD, and clinical treatments for ASD individuals should comprise an integrative approach considering the dynamics of daily rhythms in physical, mental, and social processes.
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DOI：
10.1073/pnas.0810793106
发表时间：
2009-06-23
影响因子：
11.1
作者：
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发表时间：
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影响因子：
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