A unique mechanism of successful fertilization in a domestic bird.
A unique mechanism of successful fertilization in a domestic bird.
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DOI：
10.1038/srep07700
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发表时间：
2015-01-09
影响因子：
4.6
通讯作者：
Tsutsui K
中科院分区：
文献类型：
--
作者：
Sasanami T;Izumi S;Sakurai N;Hirata T;Mizushima S;Matsuzaki M;Hiyama G;Yorinaga E;Yoshimura T;Ukena K;Tsutsui K
受精是有性生殖中合子形成的必要步骤，是物种生存的关键。当交配发生时，精子通过精浆（SP）被运送到雌性生殖道。SP来源于雄性副性腺，在动物受精过程中起着关键作用。然而，SP或来自雄性副性腺的液体成功受精的分子机制尚不清楚。在这里，我们报道了雄性鹌鹑的泄殖腔腺（CG）产生前列腺素F2α (PGF2α)，这有助于成功受精。PGF2α，以及CG （CGS）的分泌，诱导阴道收缩，并导致精子储存小管（负责长期精子储存和受精的结构）入口打开。在交配前去除CGS会降低雄性的生育能力，但补充CGS或PGF2α可以挽救低生育能力。我们进一步表明，男性CG含有葡萄糖，作为精子运输到女性阴道后内在运动的能量来源。这种机制与PGF2α的兴奋作用相一致，使家鸟成功受精。
Fertilization is an indispensable step for formation of a zygote in sexual reproduction, leading to species survival. When mating occurs, sperm is transported to the female reproductive tracts via the seminal plasma (SP). SP is derived from male accessory sex glands and it plays pivotal roles for fertilization in animals. However, molecular mechanisms of SP or a fluid derived from male accessory sex glands for successful fertilization remain unclear. Here, we report that in male quail the cloacal gland (CG) produces prostaglandin F2α (PGF2α) that contributes to successful fertilization. PGF2α, as well as the secretion of CG (CGS), induced vaginal contractions and caused the opening of the entrance of the sperm storage tubules, the structures responsible for the long-term sperm storage and fertilization. The removal of CGS from the male before mating reduced the fertility, but the supplementation of CGS or PGF2α rescued the subfertility. We further showed that male CG contains glucose that is utilized as energy source for the intrinsic sperm mobility after transportation to female vagina. This mechanism, in concert with the excitatory effects of PGF2α enables successful fertilization in the domestic bird.
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影响因子：
56.9
作者：
BERGSTROM, S
通讯作者：
BERGSTROM, S
影响因子：
3.1
作者：
BLAKENEY, AB;HARRIS, PJ;STONE, BA
通讯作者：
STONE, BA
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2.9
作者：
ANDERSEN, NH;LIN, BS
通讯作者：
LIN, BS
影响因子：
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作者：
Das, SC;Nagasaka, N;Yoshimura, Y
通讯作者：
Yoshimura, Y
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2.8
作者：
Horvat, G;Bilkei, G
通讯作者：
Bilkei, G