Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda.
Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda.
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DOI：
10.1016/j.jinf.2022.09.007
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发表时间：
2022-12
影响因子：
28.2
通讯作者：
Tweyongyere, Robert
中科院分区：
文献类型：
--
作者：
Atim, Stella A.;Ashraf, Shirin;Belij-Rammerstorfer, Sandra;Ademun, Anna R.;Vudriko, Patrick;Nakayiki, Teddy;Niebel, Marc;Shepherd, James;Balinandi, Stephen;Nakanjako, Gladys;Abaasa, Andrew;Johnson, Paul C. D.;Odongo, Steven;Esau, Martin;Bahati, Milton;Kaleebu, Pontiano;Lutwama, Julius J.;Masembe, Charles;Lambe, Teresa;Thomson, Emma C.;Tweyongyere, Robert
关键词：
乌干达畜牧业社区中克里米亚-刚果出血热病毒（CCHFV）人畜共患传播的危险因素。在乌干达的人类和家畜中检测到极高的CCHFV血清阳性率。迄今为止，在乌干达，CCHFV感染和危险因素的负担被低估了。在多个扇头蜱池中检测到CCHV表明这些蜱可能是乌干达CCHFV的载体。人类CCHFV风险与牲畜饲养有关，年龄和收集/食用蜱进一步的工作表明，估计CCHFV感染的发病率作为非疟疾热的原因克里米亚-刚果出血热（CCHF）是一种新出现的人类-在畜牧业社区造成零星爆发的健康威胁。然而，以前没有详细描述过与这些社区接触有关的全部程度和风险。我们收集了800人，666头牛，549只山羊和32只狗在乌干达牛走廊内外的地区的横断面调查的血液样本，并使用酶联免疫吸附试验检测CCHFV特异性IgG抗体。社会人口学和流行病学资料采用结构式问卷进行记录。收集蜱虫以通过宏基因组测序鉴定循环内罗病毒。CCHFV血清学阳性率在人中为221/800（27.6%），在牛中为612/666（91.8%），在山羊中为413/549（75.2%），在狗中为18/32（56.2%）。人类血清阳性与畜牧业（AOR= 5.68，p<0.0001）、年龄（AOR= 2.99，p= 0.002）和收集/食用饱食蜱（AOR= 2.13，p= 0.004）相关。在动物中，牛的血清阳性率高于山羊（AOR= 2.58，p<0.0001）、雌性（AOR= 2.13，p= 0.002）和严重蜱虫感染（>50只蜱虫：AOR= 3.52，p= 0.004）。CCHFV在多个蜱池的扇头蜱。非常高的CCHF血清阳性率，特别是在畜牧业者和多种区域风险因素相关的暴露，包括收集/食用以前未被识别的饱食蜱虫，强调需要进一步监测和敏感化以及针对该疾病的控制政策。
Risk factors for zoonotic transmission of Crimean-Congo Haemorrhagic fever Virus (CCHFV) among livestock farming communities in Uganda. Extremely high CCHFV seroprevalence was detected in humans and domestic animals in Uganda The burden of CCHFV infection and risk factors has to date been underestimated in Uganda. Detection of CCHV in multiple pools of Rhipicephalus appendiculatus suggest these ticks to be the likely vectors for CCHFV in Uganda CCHFV risk in humans were associated with livestock rearing, age and collecting/ eating ticks Further work is indicated to estimate the incidence of CCHFV infection as a cause of non-malarial fever Crimean-Congo Haemorrhagic Fever (CCHF) is an emerging human-health threat causing sporadic outbreaks in livestock farming communities. However, the full extent and the risks associated with exposure of such communities has not previously been well-described. We collected blood samples from 800 humans, 666 cattle, 549 goats and 32 dogs in districts within and outside Ugandan cattle corridor in a cross-sectional survey, and tested for CCHFV-specific IgG antibodies using Enzyme-Linked Immunosorbent Assays. Sociodemographic and epidemiological data were recorded using structured questionnaire. Ticks were collected to identify circulating nairoviruses by metagenomic sequencing. CCHFV seropositivity was in 221/800 (27·6%) in humans, 612/666 (91·8%) in cattle, 413/549 (75·2%) in goats and 18/32 (56·2%) in dogs. Human seropositivity was associated with livestock farming (AOR=5·68, p<0·0001), age (AOR=2·99, p=0·002) and collecting/eating engorged ticks (AOR=2·13, p=0·004). In animals, seropositivity was higher in cattle versus goats (AOR=2·58, p<0·0001), female sex (AOR=2·13, p=0·002) and heavy tick infestation (>50 ticks: AOR=3·52, p=0·004). CCHFV was identified in multiple tick pools of Rhipicephalus appendiculatus. The very high CCHF seropositivity especially among livestock farmers and multiple regional risk factors associated exposures, including collecting/eating engorged ticks previously unrecognised, highlights need for further surveillance and sensitisation and control policies against the disease.
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影响因子：
3.2
作者：
Sas, Miriam A.;Mertens, Marc;Groschup, Martin H.
通讯作者：
Groschup, Martin H.
影响因子：
3.8
作者：
Mirembe BB;Musewa A;Kadobera D;Kisaakye E;Birungi D;Eurien D;Nyakarahuka L;Balinandi S;Tumusiime A;Kyondo J;Mulei SM;Baluku J;Kwesiga B;Kabwama SN;Zhu BP;Harris JR;Lutwama JJ;Ario AR
通讯作者：
Ario AR
影响因子：
3.1
作者：
Balinandi, Stephen;von Bromssen, Claudia;Malmberg, Maja
通讯作者：
Malmberg, Maja
DOI：
10.1099/jgv.0.001485
发表时间：
2020-08
期刊：
The Journal of general virology
影响因子：
--
作者：
Garrison AR;Alkhovsky Альховский Сергей Владимирович SV;Avšič-Županc T;Bente DA;Bergeron É;Burt F;Di Paola N;Ergünay K;Hewson R;Kuhn JH;Mirazimi A;Papa Άννα Παπά A;Sall AA;Spengler JR;Palacios G;Consortium IR
通讯作者：
Consortium IR
影响因子：
2.1
作者：
Mangombi, Joa Brathe;Roqueplo, Cedric;Davoust, Bernard
通讯作者：
Davoust, Bernard