N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users.
N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users.
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DOI：
10.1093/ijnp/pyy042
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
London ED
中科院分区：
文献类型：
--
作者：
Tang J;O'Neill J;Alger JR;Shen Z;Johnson MC;London ED
在临床前研究中，甲基苯丙胺诱导神经元 N-乙酰基-天冬氨酸合成。在初步的人体质子磁共振波谱成像研究中，我们还观察到右下额皮质中的N-乙酰基天冬氨酸+N-乙酰基天冬氨酰谷氨酸与多年的重度甲基苯丙胺滥用相关。在同一大脑区域，甲基苯丙胺使用者的谷氨酸+谷氨酰胺含量低于对照组，并且与抑郁症呈负相关。因此，N-乙酰基和谷氨酸能神经化学值得进一步研究甲基苯丙胺滥用和相关情绪症状。使用磁共振波谱成像测量 45 名戒除甲基苯丙胺依赖者和 45 名健康对照参与者的双侧额下皮层和岛叶（受甲基苯丙胺影响的邻近侧裂区）的 N-乙酰基-天冬氨酸+N-乙酰基-天冬氨酰-谷氨酸和谷氨酸+谷氨酰胺。测试了区域神经代谢物水平的组间差异以及与大量使用甲基苯丙胺的持续时间、抑郁症状和状态焦虑的关联。在右下额皮质中，N-乙酰基-天冬氨酸+N-乙酰基-天冬氨酰-谷氨酸与多年大量使用甲基苯丙胺相关（r = +0.45）；甲基苯丙胺使用者的谷氨酸+谷氨酰胺含量低于对照组 (9.3%)，并且与抑郁症状呈负相关 (r = -0.44)。在左脑岛中，甲基苯丙胺使用者的 N-乙酰基-天冬氨酸+N-乙酰基-天冬氨酰-谷氨酸含量比对照组高 9.1%。在右岛中，甲基苯丙胺使用者的谷氨酸+谷氨酰胺含量比对照组低 12.3%，并且与抑郁症状 (r = -0.51) 和状态焦虑 (r = -0.47) 呈负相关。下额皮质和岛叶显示出与甲基苯丙胺相关的异常，这与之前在接触甲基苯丙胺的动物模型中观察到的皮质 N-乙酰基天冬氨酸增加以及人类甲基苯丙胺使用者的皮质谷氨酸和情绪之间的关联一致。
Methamphetamine induces neuronal N-acetyl-aspartate synthesis in preclinical studies. In a preliminary human proton magnetic resonance spectroscopic imaging investigation, we also observed that N-acetyl-aspartate+N-acetyl-aspartyl-glutamate in right inferior frontal cortex correlated with years of heavy methamphetamine abuse. In the same brain region, glutamate+glutamine is lower in methamphetamine users than in controls and is negatively correlated with depression. N-acetyl and glutamatergic neurochemistries therefore merit further investigation in methamphetamine abuse and the associated mood symptoms. Magnetic resonance spectroscopic imaging was used to measure N-acetyl-aspartate+N-acetyl-aspartyl-glutamate and glutamate+glutamine in bilateral inferior frontal cortex and insula, a neighboring perisylvian region affected by methamphetamine, of 45 abstinent methamphetamine-dependent and 45 healthy control participants. Regional neurometabolite levels were tested for group differences and associations with duration of heavy methamphetamine use, depressive symptoms, and state anxiety. In right inferior frontal cortex, N-acetyl-aspartate+N-acetyl-aspartyl-glutamate correlated with years of heavy methamphetamine use (r = +0.45); glutamate+glutamine was lower in methamphetamine users than in controls (9.3%) and correlated negatively with depressive symptoms (r = -0.44). In left insula, N-acetyl-aspartate+N-acetyl-aspartyl-glutamate was 9.1% higher in methamphetamine users than controls. In right insula, glutamate+glutamine was 12.3% lower in methamphetamine users than controls and correlated negatively with depressive symptoms (r = -0.51) and state anxiety (r = -0.47). The inferior frontal cortex and insula show methamphetamine-related abnormalities, consistent with prior observations of increased cortical N-acetyl-aspartate in methamphetamine-exposed animal models and associations between cortical glutamate and mood in human methamphetamine users.
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3.1
作者：
Medford, Nick;Critchley, Hugo D.
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影响因子：
7.6
作者：
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通讯作者：
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