Development of tactile sensory circuits in the CNS.

Development of tactile sensory circuits in the CNS.
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DOI:
10.1016/j.conb.2018.06.001
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发表时间:
2018-12
影响因子:
5.7
通讯作者:
Erzurumlu RS
Erzurumlu RS
中科院分区:
医学2区
文献类型:
--
作者:
Iwasato T;Erzurumlu RS

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Molecular identification of neuronal types and genetic and imaging approaches to characterize their properties reveal morphological, physiological and dynamic aspects of sensory circuit development. Here we focus on the mouse tactile sensory circuitry, with particular emphasis on the main trigeminal pathway that connects the whiskers, the major tactile organ in rodents, to the neocortex. At each level of this pathway, neurogenesis, axonal elongation, pathfinding, target recognition and circuit reorganization including dendritic refinement of cortical layer 4 neurons occur contemporaneously and a multitude of molecular signals are used in differing combinations. We highlight recent advances in development of tactile circuitry and note gaps in our understanding.
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