Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease.
Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease.
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DOI：
10.1002/mds.22782
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发表时间：
2010
影响因子：
8.6
通讯作者：
Jakowec, Michael W.
中科院分区：
文献类型：
--
作者：
Petzinger, Giselle M.;Fisher, Beth E.;Van Leeuwen, Jon-Eric;Vukovic, Marta;Akopian, Garnik;Meshul, Charlie K.;Holschneider, Daniel P.;Nacca, Angelo;Walsh, John P.;Jakowec, Michael W.
Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson’s disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD.
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影响因子：
5
作者：
Mortensen, OV;Amara, SG
通讯作者：
Amara, SG
影响因子：
4.3
作者：
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Kang, J
影响因子：
14.5
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Matthews, PM
DOI：
10.1073/pnas.90.16.7451
发表时间：
1993-08-15
影响因子：
11.1
作者：
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通讯作者：
MARSHALL, JF
DOI：
10.1016/j.apmr.2005.10.016
发表时间：
2006-02-01
影响因子：
4.3
作者：
Forrester, LW;Hanley, DF;Macko, RF
通讯作者：
Macko, RF