Long non-coding RNAs in the regulation of myeloid cells.

Long non-coding RNAs in the regulation of myeloid cells.
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长链非编码RNA在骨髓细胞调控中的作用

DOI:
10.1186/s13045-016-0333-7
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发表时间:
2016-09-29
影响因子:
28.5
通讯作者:
Wang S
Wang S
中科院分区:
医学1区
文献类型:
--
作者:
Tian X;Tian J;Tang X;Ma J;Wang S

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长链非编码RNA(lncRNA)是近年来研究的热点。随着对lncRNA各种调控机制的理解,lncRNA在生物学和生理学以及病理学过程中的相关性沿着增加。大量研究表明lncRNA参与不同类型细胞的分化、增殖、活化和凋亡的启动。然而,目前大多数关于lncRNA调节生物学的研究都集中在癌细胞上。本文综述了lncRNA在髓系细胞命运中广泛未探索的作用。在这篇综述中,我们总结了最近的研究,已证实lncRNA是必不可少的在正常和病理条件下的骨髓细胞的发展。
Long non-coding RNAs (lncRNAs) have been attracting immense research interests. The relevance of lncRNAs in biological and physiological as well as in pathological processes has increased along with the understanding of their various regulatory mechanisms. Abundant studies have indicated that lncRNAs are involved in the differentiation, proliferation, activation, and initiation of apoptosis in different cell types. However, most studies about the regulating biology of lncRNAs are currently focused on cancer cells. This review is focused on the widely unexplored role of lncRNAs in the cell fate of myeloid cells. In this review, we summarize recent studies that have confirmed lncRNAs to be essential in the development of myeloid cells under normal and pathological conditions.
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