Source memory in the rat.
Source memory in the rat.
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DOI：
10.1016/j.cub.2013.01.023
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发表时间：
2013-03-04
期刊：
影响因子：
9.2
通讯作者：
Hohmann, Andrea G.
中科院分区：
文献类型：
--
作者：
Crystal, Jonathon D.;Alford, Wesley T.;Zhou, Wenyi;Hohmann, Andrea G.
来源记忆是对信息来源的表征。当源信息被绑定在一起时，它会使记忆成为情景，使我们能够区分一个事件与另一个事件。在这里，我们问老鼠是否记得编码信息的来源。根据来源信息规则，老鼠会在最近遇到的位置觅食独特口味的食物，这些食物会补充（或未能补充）。为了预测补充，老鼠需要记住他们在哪里遇到了一种首选的食物类型（巧克力），并有自发的（沿着跑道行走时遇到了巧克力）或实验者产生的（实验者将老鼠放在巧克力位置）线索。有三种证据表明存在源记忆。首先，大鼠选择性地调整重访巧克力位置的基础上源信息，在熟悉的事件不能产生成功的性能的条件下。第二，源记忆和位置记忆以不同的衰减速率分离。第三，暂时失活的海马CA3区与利多卡因选择性地消除源记忆，这表明源记忆是依赖于一个完整的海马。源记忆动物模型的发展可能是有价值的，以探讨生物学基础的记忆障碍的标志在源记忆的损害。
Source memory is a representation of the origin (source) of information. When source information is bound together, it makes a memory episodic, allowing us to differentiate one event from another. Here we asked if rats remember the source of encoded information. Rats foraged for distinctive flavors of food that replenished (or failed to replenish) at its recently encountered location according to a source-information rule. To predict replenishment, rats needed to remember where they had encountered a preferred food type (chocolate) with self-generated (walking along a runway encountering chocolate) or experimenter-generated (placement of the rat at the chocolate site by an experimenter) cues. Three lines of evidence implicate the presence of source memory. First, rats selectively adjusted revisits to the chocolate location based on source information, under conditions in which familiarity of events could not produce successful performance. Second, source memory was dissociated from location memory by different decay rates. Third, temporary inactivation of the CA3 region of the hippocampus with lidocaine selectively eliminated source memory, suggesting that source memory is dependent upon an intact hippocampus. Development of an animal model of source memory may be valuable to probe the biological underpinnings of memory disorders marked by impairments in source memory.
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