Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions.
Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions.
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DOI：
10.3390/nu13124374
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发表时间：
2021-12-06
期刊：
影响因子：
5.9
通讯作者：
Tobe K
中科院分区：
文献类型：
--
作者：
Nawaz A;Nishida Y;Takikawa A;Fujisaka S;Kado T;Aminuddin A;Bilal M;Jeelani I;Aslam MR;Nishimura A;Kuwano T;Watanabe Y;Igarashi Y;Okabe K;Ahmed S;Manzoor A;Usui I;Yagi K;Nakagawa T;Tobe K
近年来，肥胖引起的胰岛素抵抗、2型糖尿病和心血管疾病已成为主要的社会问题。我们之前已经证明虾青素（AX）是一种天然抗氧化剂，可以显著改善肥胖引起的葡萄糖耐受不良和胰岛素抵抗。众所周知，AX是一种强亲脂性抗氧化剂，已被证明对急性炎症有益。然而，AX对脂肪组织慢性炎症（AT）的实际作用尚不清楚。为了观察AX对肥胖小鼠AT功能的影响，我们给6周龄雄性C57BL/6J喂食添加或不添加0.02% AX的高脂饲料（HFD） 24周。我们测定了在HFD治疗10周和24周时，有或没有AX对胰岛素敏感性、葡萄糖耐量、炎症和线粒体功能等各种参数的影响。我们发现，AX显著降低氧化应激和巨噬细胞对AT的浸润，并维持健康的AT功能。此外，AX对可能由AT缺氧引起的病理性AT重塑具有抑制作用。综上所述，AX处理通过其在AT中的抗氧化活性发挥抗炎作用，维持AT的血管结构，保存干细胞和祖细胞的生态位，增强抗炎缺氧诱导因子-2α-优势的缺氧反应。通过这些作用机制，它阻止了AT的病理性重塑，保持了AT的完整性。
Recently, obesity-induced insulin resistance, type 2 diabetes, and cardiovascular disease have become major social problems. We have previously shown that Astaxanthin (AX), which is a natural antioxidant, significantly ameliorates obesity-induced glucose intolerance and insulin resistance. It is well known that AX is a strong lipophilic antioxidant and has been shown to be beneficial for acute inflammation. However, the actual effects of AX on chronic inflammation in adipose tissue (AT) remain unclear. To observe the effects of AX on AT functions in obese mice, we fed six-week-old male C57BL/6J on high-fat-diet (HFD) supplemented with or without 0.02% of AX for 24 weeks. We determined the effect of AX at 10 and 24 weeks of HFD with or without AX on various parameters including insulin sensitivity, glucose tolerance, inflammation, and mitochondrial function in AT. We found that AX significantly reduced oxidative stress and macrophage infiltration into AT, as well as maintaining healthy AT function. Furthermore, AX prevented pathological AT remodeling probably caused by hypoxia in AT. Collectively, AX treatment exerted anti-inflammatory effects via its antioxidant activity in AT, maintained the vascular structure of AT and preserved the stem cells and progenitor’s niche, and enhanced anti-inflammatory hypoxia induction factor-2α-dominant hypoxic response. Through these mechanisms of action, it prevented the pathological remodeling of AT and maintained its integrity.
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脂肪生成过程中脂肪细胞祖细胞的命运在喂养高脂饮食的小鼠中。
影响因子：
8.1
作者：
Bilal M;Nawaz A;Kado T;Aslam MR;Igarashi Y;Nishimura A;Watanabe Y;Kuwano T;Liu J;Miwa H;Era T;Ikuta K;Imura J;Yagi K;Nakagawa T;Fujisaka S;Tobe K
通讯作者：
Tobe K
影响因子：
5.9
作者：
Landrier JF;Marcotorchino J;Tourniaire F
通讯作者：
Tourniaire F
影响因子：
6.1
作者：
Hussein, Ghazi;Nakagawa, Takako;Watanabe, Hiroshi
通讯作者：
Watanabe, Hiroshi
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.
DOI：
10.1161/hypertensionaha.111.174128
发表时间：
2011-10
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Hu X;Xu X;Lu Z;Zhang P;Fassett J;Zhang Y;Xin Y;Hall JL;Viollet B;Bache RJ;Huang Y;Chen Y
通讯作者：
Chen Y