Neurobehavioral function in school-age children exposed to manganese in drinking water.
Neurobehavioral function in school-age children exposed to manganese in drinking water.
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DOI：
10.1289/ehp.1307918
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发表时间：
2014-12
影响因子：
10.4
通讯作者：
Bouchard MF
中科院分区：
文献类型：
--
作者：
Oulhote Y;Mergler D;Barbeau B;Bellinger DC;Bouffard T;Brodeur MÈ;Saint-Amour D;Legrand M;Sauvé S;Bouchard MF
背景：对于因职业接触空气颗粒物的个体而言，锰的神经毒性已得到充分记录，但有关饮用水接触风险的数据却很少。目的：我们研究了水和头发中锰浓度的暴露与记忆、注意力、运动功能以及家长和老师报告的过度活跃行为之间的关系。方法：我们招募了 375 名儿童，测量了家庭自来水 (MnW) 和头发 (MnH) 中的锰含量。我们估算了饮水过程中锰的摄入量。使用结构方程模型，我们估计了神经行为功能与水中 MnH、MnW 和锰摄入量之间的关联。我们使用广义相加模型评估了暴露-反应关系。结果：调整潜在的混杂因素后，log10 MnH 的 1-SD 增加与记忆力的 –24% (95% CI: –36, –12%) SD 和注意力的 –25% (95% CI: –41, –9%) SD 的显着差异相关。 log10 MnH 与较差的记忆力和注意力之间的关系是线性的。 log10 MnW 的 1-SD 增加与记忆中 –14% (95% CI: –24, –4%) SD 的显着差异相关，并且这种关系是非线性的，MnW > 100 μg/L 时性能下降更剧烈。从水中摄入 log10 锰的 1-SD 增加与运动功能的 –11% (95% CI: –21, –0.4%) SD 显着差异相关。 log10 锰摄入量与运动功能较差之间呈线性关系。锰暴露与多动症之间没有显着关联。结论：接触水中的锰与儿童神经行为表现较差有关，即使是在北美常见的低水平锰。引用: Oulhote Y、Mergler D、Barbeau B、Bellinger DC、Bouffard T、Brodeur ME、Saint-Amour D、Legrand M、Sauvé S、Bouchard MF。 2014.接触饮用水中锰的学龄儿童的神经行为功能。环境健康视角 122：1343–1350； http://dx.doi.org/10.1289/ehp.1307918
Background: Manganese neurotoxicity is well documented in individuals occupationally exposed to airborne particulates, but few data are available on risks from drinking-water exposure. Objective: We examined associations of exposure from concentrations of manganese in water and hair with memory, attention, motor function, and parent- and teacher-reported hyperactive behaviors. Methods: We recruited 375 children and measured manganese in home tap water (MnW) and hair (MnH). We estimated manganese intake from water ingestion. Using structural equation modeling, we estimated associations between neurobehavioral functions and MnH, MnW, and manganese intake from water. We evaluated exposure–response relationships using generalized additive models. Results: After adjusting for potential confounders, a 1-SD increase in log10 MnH was associated with a significant difference of –24% (95% CI: –36, –12%) SD in memory and –25% (95% CI: –41, –9%) SD in attention. The relations between log10 MnH and poorer memory and attention were linear. A 1-SD increase in log10 MnW was associated with a significant difference of –14% (95% CI: –24, –4%) SD in memory, and this relation was nonlinear, with a steeper decline in performance at MnW > 100 μg/L. A 1-SD increase in log10 manganese intake from water was associated with a significant difference of –11% (95% CI: –21, –0.4%) SD in motor function. The relation between log10 manganese intake and poorer motor function was linear. There was no significant association between manganese exposure and hyperactivity. Conclusion: Exposure to manganese in water was associated with poorer neurobehavioral performances in children, even at low levels commonly encountered in North America. Citation: Oulhote Y, Mergler D, Barbeau B, Bellinger DC, Bouffard T, Brodeur ME, Saint-Amour D, Legrand M, Sauvé S, Bouchard MF. 2014. Neurobehavioral function in school-age children exposed to manganese in drinking water. Environ Health Perspect 122:1343–1350; http://dx.doi.org/10.1289/ehp.1307918
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影响因子：
11.4
作者：
Eastman, Rachel R.;Jursa, Tom P.;Benedetti, Chiara;Lucchini, Roberto G.;Smith, Donald R.
通讯作者：
Smith, Donald R.
影响因子：
10.4
作者：
Bouchard MF;Sauvé S;Barbeau B;Legrand M;Brodeur MÈ;Bouffard T;Limoges E;Bellinger DC;Mergler D
通讯作者：
Mergler D
影响因子：
4.7
作者：
Guilarte, Tomas R.;Burton, Neal C.;Schneider, Jay S.
通讯作者：
Schneider, Jay S.
DOI：
10.1080/02652030210140905
发表时间：
2002-08-01
期刊：
FOOD ADDITIVES AND CONTAMINANTS
影响因子：
--
作者：
Dabeka, RW;Conacher, HBS;Pepper, K
通讯作者：
Pepper, K
影响因子：
10.4
作者：
Khan K;Factor-Litvak P;Wasserman GA;Liu X;Ahmed E;Parvez F;Slavkovich V;Levy D;Mey J;van Geen A;Graziano JH
通讯作者：
Graziano JH