Manganese exposure from drinking water and children's classroom behavior in Bangladesh.
Manganese exposure from drinking water and children's classroom behavior in Bangladesh.
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DOI：
10.1289/ehp.1003397
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发表时间：
2011-10
影响因子：
10.4
通讯作者：
Graziano JH
中科院分区：
文献类型：
--
作者：
Khan K;Factor-Litvak P;Wasserman GA;Liu X;Ahmed E;Parvez F;Slavkovich V;Levy D;Mey J;van Geen A;Graziano JH
背景资料：饮用水锰暴露对儿童神经、认知和神经心理学影响的证据已引起广泛的公共卫生关注。在高暴露量下，锰与外化行为水平的增加有关，包括易怒、攻击性和冲动性。关于低暴露量的潜在影响，特别是对儿童的影响，我们知之甚少。此外，很少有人知道锰和其他金属，特别是砷（As）之间的潜在相互作用。目的：我们进行了一项横断面研究，201名儿童调查协会的锰和砷管井水与小学生，8 - 11岁，在Araihazar，孟加拉国的课堂行为。研究方法：在一项正在进行的儿童智力纵向研究的基线上，从参与者那里收集了关于暴露和行为结果的数据。研究的儿童进行了评估，他们的学校教师使用标准化的儿童行为检查表，教师的报告表（CBCL-TRF）的课堂行为的外化和内化项目。结果如下：对数转换的WMn与TRF内化（估计β = 0.82; 95%置信区间（CI），0.08 - 1.56; p = 0.03）、TRF外化（估计β = 0.82; 95%置信区间（CI），0.08 - 1.56; p = 0.03）、TRF外化（估计β = 0.82; 95%置信区间（CI），0.08 - 1.56; p = 0.03）和TRF外化（估计β = 0.82; 95%置信区间（CI），0.08 - 1.56; p = 0.03）呈正相关。（估计β = 2.59; 95% CI，0.81 - 4.37; p = 0.004）和TRF总分（估计β = 3.35; 95% CI，0.86 - 5.83; p = 0.008），校正了对数转换的水砷（WA）和社会人口统计学协变量。我们还观察到WMn和TRF外化和TRF总分之间的正单调剂量反应关系的研究的参与者。我们没有发现任何显着的关联WAs和各种规模的TRF分数。结论：这些观察结果加强了对WMn在儿童中的神经毒性作用的日益关注。
Background: Evidence of neurological, cognitive, and neuropsychological effects of manganese (Mn) exposure from drinking water (WMn) in children has generated widespread public health concern. At elevated exposures, Mn has been associated with increased levels of externalizing behaviors, including irritability, aggression, and impulsivity. Little is known about potential effects at lower exposures, especially in children. Moreover, little is known regarding potential interactions between exposure to Mn and other metals, especially arsenic (As). Objectives: We conducted a cross-sectional study of 201 children to investigate associations of Mn and As in tube well water with classroom behavior among elementary school children, 8–11 years of age, in Araihazar, Bangladesh. Methods: Data on exposures and behavioral outcomes were collected from the participants at the baseline of an ongoing longitudinal study of child intelligence. Study children were rated by their school teachers on externalizing and internalizing items of classroom behavior using the standardized Child Behavior Checklist-Teacher’s Report Form (CBCL-TRF). Results: Log-transformed WMn was positively and significantly associated with TRF internalizing [estimated β = 0.82; 95% confidence interval (CI), 0.08–1.56; p = 0.03], TRF externalizing (estimated β = 2.59; 95% CI, 0.81–4.37; p =0.004), and TRF total scores (estimated β = 3.35; 95% CI, 0.86–5.83; p = 0.008) in models that adjusted for log-transformed water arsenic (WAs) and sociodemographic covariates. We also observed a positive monotonic dose–response relationship between WMn and TRF externalizing and TRF total scores among the participants of the study. We did not find any significant associations between WAs and various scales of TRF scores. Conclusion: These observations reinforce the growing concern regarding the neurotoxicologic effects of WMn in children.
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影响因子：
3.4
作者：
Laohaudomchok W;Lin X;Herrick RF;Fang SC;Cavallari JM;Shrairman R;Landau A;Christiani DC;Weisskopf MG
通讯作者：
Weisskopf MG
影响因子：
5
作者：
HEINEGAR.D;TIDERSTR.G
通讯作者：
TIDERSTR.G
影响因子：
3.4
作者：
Ellingsen, Dag G.;Konstantinov, Roman;Chashchin, Valery
通讯作者：
Chashchin, Valery
影响因子：
5.3
作者：
Guilarte, Tomas R.;Chen, Ming-Kai;Schneider, Jay S.
通讯作者：
Schneider, Jay S.
影响因子：
10.4
作者：
Bouchard MF;Sauvé S;Barbeau B;Legrand M;Brodeur MÈ;Bouffard T;Limoges E;Bellinger DC;Mergler D
通讯作者：
Mergler D