Coronary microvascular resistance: methods for its quantification in humans.

Coronary microvascular resistance: methods for its quantification in humans.
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冠状动脉微血管抵抗:其在人类中进行定量的方法。

DOI:
10.1007/s00395-009-0037-z
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发表时间:
2009-09
影响因子:
9.5
通讯作者:
van Rossum AC
van Rossum AC
中科院分区:
医学1区
文献类型:
--
作者:
Knaapen P;Camici PG;Marques KM;Nijveldt R;Bax JJ;Westerhof N;Götte MJ;Jerosch-Herold M;Schelbert HR;Lammertsma AA;van Rossum AC

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冠状动脉微血管功能障碍是一个话题,最近获得了相当大的兴趣,在医学界,由于越来越多的认识到,微血管功能障碍发生在一些心肌疾病的状态,并具有重要的预后意义。随着这种认识的不断提高,人们希望准确评估冠状动脉微循环的功能能力以用于诊断目的,以及监测旨在逆转冠状动脉微血管功能障碍程度的治疗干预的效果。冠状动脉微血管阻力的测量在实现这一目标中起着关键作用,并且已经开发了几种有创和无创的方法用于其定量。本综述旨在提供有关这些不同成像技术方法的最新信息,包括讨论它们的优点和缺点。
Coronary microvascular dysfunction is a topic that has recently gained considerable interest in the medical community owing to the growing awareness that microvascular dysfunction occurs in a number of myocardial disease states and has important prognostic implications. With this growing awareness, comes the desire to accurately assess the functional capacity of the coronary microcirculation for diagnostic purposes as well as to monitor the effects of therapeutic interventions that are targeted at reversing the extent of coronary microvascular dysfunction. Measurements of coronary microvascular resistance play a pivotal role in achieving that goal and several invasive and noninvasive methods have been developed for its quantification. This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses.
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