Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution.
Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution.
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DOI：
10.1016/j.bioactmat.2021.11.030
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发表时间：
2022-09
影响因子：
18.9
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Liu X;Mao X;Ye G;Wang M;Xue K;Zhang Y;Zhang H;Ning X;Zhao M;Song J;Zhang YS;Zhang X
近年来，当地药物递送越来越受到关注。然而，在某些情况下，例如在口腔中或在肿瘤切除后的伤口床中，药物的局部递送的治疗功效仍然有限。在这项研究中，我们介绍了一种生物启发的粘合剂水凝胶来自皮肤分泌物的大鲵（SSAD）作为伤口敷料局部药物洗脱。水凝胶负载氨基胍或阿霉素，其控制药物释放和愈合促进性能进行了验证，在糖尿病大鼠腭粘膜缺损模型和C57 BL/6小鼠黑色素瘤荷瘤模型，分别。结果表明，不同孔径的SSAD水凝胶能够以可控的方式释放药物，促进伤口愈合。腭粘膜的转录组分析表明，SSAD可以显着上调与细胞粘附和细胞外基质沉积的途径，并有能力招募角质形成干细胞缺损部位。综上所述，这些发现表明，性能可控的SSAD水凝胶可能是一种有前途的生物功能性伤口敷料，用于局部药物递送和促进伤口愈合。SSAD是一种生物可提取的来源，具有易于生产，成本效益和安全性。SSAD通过局部应用增加药物生物利用度。药物释放速率可以通过调节SSAD粒径来控制。SSAD基伤口敷料具有粘性。SSAD还可以促进伤口愈合。
Local drug delivery has received increasing attention in recent years. However, the therapeutic efficacy of local delivery of drugs is still limited under certain scenarios, such as in the oral cavity or in wound beds after resection of tumors. In this study, we introduce a bioinspired adhesive hydrogel derived from the skin secretions of Andrias davidianus (SSAD) as a wound dressing for localized drug elution. The hydrogel was loaded with aminoguanidine or doxorubicin, and its controlled drug release and healing-promoting properties were verified in a diabetic rat palatal mucosal defect model and a C57BL/6 mouse melanoma-bearing model, respectively. The results showed that SSAD hydrogels with different pore sizes could release drugs in a controllable manner and accelerate wound healing. Transcriptome analyses of the palatal mucosa suggested that SSAD could significantly upregulate pathways linked to cell adhesion and extracellular matrix deposition and had the ability to recruit keratinocyte stem cells to defect sites. Taken together, these findings indicate that property-controllable SSAD hydrogels could be a promising biofunctional wound dressing for local drug delivery and promotion of wound healing. The SSAD is a biologically drawable source with facile production, cost-effective, and safe. SSAD increases drug bioavailability with local application. The drug release rate can be controlled by regulating SSAD particle size. The SSAD-based wound dressing is adhesive. SSAD can also promote wound healing.
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