The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
复制标题
以TLR4信号通路为靶点的植物活性物质的抗癌、抗炎和抗氧化作用。
DOI：
10.3390/ijms19092729
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发表时间：
2018-09-12
影响因子：
5.6
通讯作者：
Liu CM
中科院分区：
文献类型：
--
作者：
Chen CY;Kao CL;Liu CM
Toll样受体（TLR）是一个众所周知的模式识别受体家族，在宿主免疫系统中发挥重要作用。TLR触发导致促炎细胞因子和趋化因子的诱导，从而驱动先天免疫和适应性免疫两者的激活。最近，越来越多的研究表明TLR与癌症之间的联系。其中，Toll样受体4（TLR 4）信号通路与炎症反应和癌症进展相关。膳食植物化学物质是潜在的免疫状态调节剂，具有抗癌、抗氧化和抗炎等多种药理学特性。姜黄素、6-姜辣素、6-姜烯酚、1-姜-10-姜二酮、表没食子儿茶素没食子酸酯（EGCG）、毛地黄黄酮、槲皮素、白藜芦醇、咖啡酸苯乙酯、黄腐酚、染料木素、小檗碱和萝卜硫素可以抑制TLR 4活化。本综述的目的是描述TLR 4信号通路在炎症反应和癌症进展之间的作用。我们进一步介绍了生物活性的植物化学物质与潜在的抗炎和化学预防抑制TLR激活。
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune system. TLR triggering leads to the induction of pro-inflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity. Recently, an increasing number studies have shown the link between TLRs and cancer. Among them, the toll-like receptor 4 (TLR4) signaling pathway is associated with inflammatory response and cancer progression. Dietary phytochemicals are potential modulators of immunological status with various pharmacological properties including anti-cancer, anti-oxidant and anti-inflammatory. Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-gingerdione, epigallocatechin gallate (EGCG), luteolin, quercetin, resveratrol, caffeic acid phenethyl ester, xanthohumol, genistein, berberine, and sulforaphane can inhibit TLR4 activation. The aim of the present review is to describe the role of the TLR4 signaling pathway between inflammatory response and cancer progression. We further introduce bioactive phytochemicals with potential anti-inflammation and chemoprevention by inhibiting TLR activation.
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影响因子：
10.7
作者：
Das UN
通讯作者：
Das UN
Toll样受体在炎症和肿瘤免疫中的作用
影响因子：
5.6
作者：
Cen X;Liu S;Cheng K
通讯作者：
Cheng K
影响因子：
5.9
作者：
Dei Cas M;Ghidoni R
通讯作者：
Ghidoni R
蜂胶乙醇提取物及其成分咖啡酸苯乙酯通过抑制TLR4信号通路、诱导细胞凋亡和自噬抑制炎症微环境中乳腺癌细胞增殖
影响因子：
--
作者：
Chang H;Wang Y;Yin X;Liu X;Xuan H
通讯作者：
Xuan H
影响因子：
5.6
作者：
Cho, Young-Chang;Kim, Hyun Jung;Kang, Bok Yun
通讯作者：
Kang, Bok Yun