Deleted in Colorectal Cancer (DCC) pathfinding: axon guidance gene finally turned tumor suppressor.
Deleted in Colorectal Cancer (DCC) pathfinding: axon guidance gene finally turned tumor suppressor.
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DOI：
10.2174/138945012803530215
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发表时间：
2012-10
影响因子：
3.2
通讯作者：
Duman-Scheel M
中科院分区：
文献类型：
--
作者：
Duman-Scheel M
人类染色体18 q上的杂合性缺失（洛），包括结直肠癌（DCC）中的基因缺失，与结直肠癌和许多其他人类癌症有关。DCC编码轴突导向分子Netrin（Net）的受体，并在多种生物体的神经发育过程中发挥作用。然而，自20世纪90年代发现以来，DCC作为肿瘤抑制因子的地位一直存在争议，主要是由于在动物模型中缺乏对这一假设的支持。我们实验室最近的一项研究利用了果蝇的遗传可塑性，证明该基因作为侵袭性肿瘤抑制因子发挥作用，从而在癌症动物模型中首次提供了DCC丢失和转移表型之间的直接联系。其他实验室的两项后续研究表明，DCC可抑制小鼠结直肠和乳腺肿瘤模型中的肿瘤进展和转移。结合起来，这些发现促使DCC作为肿瘤抑制剂的重生，并强调了在人类癌症动物模型中继续分析DCC功能的必要性。
Loss of heterozygosity (LOH) at human chromosome 18q, which includes the gene Deleted in Colorectal Cancer (DCC), has been linked to colorectal and many other human cancers. DCC encodes the receptor for the axon guidance molecule Netrin (Net) and functions during neural development in a variety of organisms. However, since its discovery in the 1990s, the status of DCC as a tumor suppressor has been debated, primarily due to a lack of support for this hypothesis in animal models. A recent study from our laboratory capitalized on the genetic tractability of Drosophila melanogaster to demonstrate that this gene functions as an invasive tumor suppressor, thereby providing the first direct link between DCC loss and metastatic phenotypes in an animal model for cancer. Two subsequent studies from other laboratories have demonstrated that DCC suppresses tumor progression and metastasis in murine colorectal and mammary tumor models. Combined, these findings have prompted the rebirth of DCC as a tumor suppressor and highlighted the need for continued analysis of DCC function in animal models for human cancer.
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影响因子：
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