The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease - Evidence from epidemiological and animal studies.
The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease - Evidence from epidemiological and animal studies.
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DOI：
10.1016/j.bj.2018.06.001
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发表时间：
2018-06
影响因子：
5.5
通讯作者：
Kitazawa M
中科院分区：
文献类型：
--
作者：
Kilian J;Kitazawa M
随着阿尔茨海默病(AD)和其他神经退行性疾病的发病率上升，人们对环境因素越来越感兴趣，这些因素可能有助于疾病的发生和发展。几十年来，空气污染一直被认为是一种主要的健康危害。虽然它对心肺发病率和死亡率的影响已被广泛研究，但越来越多的证据表明，暴露在污染空气中与各个年龄段的认知功能受损以及在晚年患阿尔茨海默病和其他痴呆症的风险增加有关；这种联系在与交通有关的污染物方面尤其明显，如二氧化氮、一氧化二氮、炭黑和小直径空气中的固体和液体，称为颗粒物。空气污染物介导中枢神经系统(CNS)神经毒性并导致认知功能下降和阿尔茨海默病(AD)的确切机制在很大程度上仍不清楚。使用动物和细胞培养模型的研究表明，暴露在污染空气中的成分会改变淀粉样β蛋白的加工、抗氧化防御和炎症。在这篇综述中，我们总结了最近的证据，支持暴露在空气污染中是所有年龄段的认知能力下降和晚年阿尔茨海默病的风险。此外，我们回顾了目前研究空气污染物在中枢神经系统中介导损害的分子机制的工作。对空气污染及其成分的神经毒性影响的了解仍然有限，进一步的研究对于更好地了解空气污染与认知能力下降之间的细胞和分子机制至关重要。
As incidence of Alzheimer's disease (AD) and other neurodegenerative diseases rise, there is increasing interest in environmental factors which may contribute to disease onset and progression. Air pollution has been known as a major health hazard for decades. While its effects on cardiopulmonary morbidity and mortality have been extensively studied, growing evidence has emerged that exposure to polluted air is associated with impaired cognitive functions at all ages and increased risk of AD and other dementias in later life; this association is particularly notable with traffic related pollutants such as nitrogen dioxide, nitrous oxide, black carbon, and small diameter airborne solids and liquids known as particulate matter. The exact mechanisms by which air pollutants mediate neurotoxicity in the central nervous system (CNS) and lead to cognitive decline and AD remain largely unknown. Studies using animal and cell culture models indicate that amyloid-beta processing, anti-oxidant defense, and inflammation are altered following the exposure to constituents of polluted air. In this review, we summarize recent evidence supporting exposure to air pollution as a risk for cognitive decline at all ages and AD at later lifetime. Additionally, we review the current body of work investigating the molecular mechanisms by which air pollutants mediate damage in the CNS. Understanding of the neurotoxic effects of air pollution and its constituents is still limited, and further studies will be essential to better understand the cellular and molecular mechanisms linking air pollution and cognitive decline.
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影响因子：
2.1
作者：
Brueckmann, Sascha;Brenn, Anja;Vogelgesang, Silke
通讯作者：
Vogelgesang, Silke
DOI：
10.1016/j.socscimed.2016.11.019
发表时间：
2017-01
期刊：
Social science & medicine (1982)
影响因子：
--
作者：
Ailshire J;Karraker A;Clarke P
通讯作者：
Clarke P
影响因子：
6.8
作者：
Cacciottolo M;Wang X;Driscoll I;Woodward N;Saffari A;Reyes J;Serre ML;Vizuete W;Sioutas C;Morgan TE;Gatz M;Chui HC;Shumaker SA;Resnick SM;Espeland MA;Finch CE;Chen JC
通讯作者：
Chen JC
影响因子：
2.5
作者：
Calderon-Garciduenas, Lilian;Engle, Randall;D'Angiulli, Amedeo
通讯作者：
D'Angiulli, Amedeo
影响因子：
5
作者：
Ailshire, Jennifer A.;Crimmins, Eileen M.
通讯作者：
Crimmins, Eileen M.