Behavioral effects of peripheral corticotropin-releasing factor during maternal separation may be mediated by proinflammatory activity.
Behavioral effects of peripheral corticotropin-releasing factor during maternal separation may be mediated by proinflammatory activity.
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DOI：
10.1016/j.psyneuen.2010.12.011
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发表时间：
2011-08
影响因子：
3.7
通讯作者：
Schiml, Patricia A.
中科院分区：
文献类型：
--
作者：
Hennessy, Michael B.;Fitch, Christopher;Jacobs, Sarah;Deak, Terrence;Schiml, Patricia A.
关键词：
当豚鼠幼崽在一个新的环境中与它们的母亲分开时，最初的主动行为（发声，运动活动）在一个小时左右后减弱，取而代之的是第二个被动阶段，其特征是蹲姿，闭上眼睛和广泛的立毛。如果在测试前给予幼仔外周注射7-14 μg促肾上腺皮质激素释放因子（CRF），则在分离后立即发生被动行为。我们发现，相对于载体输注，脑室内输注1-10 μg CRF不会增加被动行为，但外周注射抗炎细胞因子白细胞介素-10可减弱外周注射CRF诱导的被动行为。这些结果与先前的发现一起表明，外周CRF给药通过涉及外周促炎活性的机制影响分离的豚鼠幼仔的行为。内源性外周CRF的行为反应中未处理的幼崽在母亲分离的可能作用被认为是。
When guinea pig pups are separated from their mothers in a novel environment, an initial period of active behavior (vocalizing, locomotor activity) wanes after an hour or so and is replaced by a second, passive stage characterized by a crouched stance, closed eyes, and extensive piloerection. If pups are given a peripheral injection of 7–14 μg of corticotropin-releasing factor (CRF) prior to testing, the passive behaviors occur immediately upon separation. We found that intracerebroventricular infusion of 1–10 μg of CRF did not increase passive behavior relative to vehicle infusion, but that peripheral injection of the anti-inflammatory cytokine, Interleukin-10, attenuated the passive behavior induced by peripheral CRF injection. These results together with previous findings suggest that peripheral CRF administration affects behavior of separated guinea pig pups through a mechanism that involves peripheral proinflammatory activity. The possible role of endogenous peripheral CRF in the behavioral response of untreated pups during maternal separation is considered.
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