Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans.
Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans.
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DOI：
10.1038/ijo.2016.124
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发表时间：
2016-11
影响因子：
4.9
通讯作者：
Saito, M.
中科院分区：
文献类型：
--
作者：
Hibi, M.;Oishi, S.;Matsushita, M.;Yoneshiro, T.;Yamaguchi, T.;Usui, C.;Yasunaga, K.;Katsuragi, Y.;Kubota, K.;Tanaka, S.;Saito, M.
棕色脂肪组织（BAT）是一个潜在的治疗肥胖和糖尿病的目标，通过产热和底物处置冷暴露。然而，BAT在热中性条件下能量代谢中的作用仍存在争议。我们评估了BAT对能量消耗（EE）的贡献，特别是饮食诱导的产热（DIT），以及成人的底物利用。在这项横断面研究中，在冷暴露（19 °C）后，使用18 F-氟-2-脱氧-D-葡萄糖正电子发射断层扫描结合计算机断层扫描（18 F-FDG-PET/CT）对21名男性的BAT活性进行了评估。根据18F-FDG-PET/CT结果将受试者分为BAT阳性组（n=13）和BAT阴性组（n=8）。使用全室间接热量计在27 °C下测量24小时EE、DIT和呼吸商。两组之间的身体成分、血液代谢物和24小时EE没有差异。然而，以DIT除以总能量摄入计算的DIT（%）在BAT阳性组中显著更高（BAT阳性：9.7± 2.5%，BAT阴性：6.5± 4.0%，P=0.03）。BAT阳性组24 h呼吸商（0.861±0.027）显著低于BAT阴性组（0.889±0.024）（P=0.03）。BAT阳性受试者的DIT和脂肪利用率高于BAT阴性受试者，表明BAT在能量代谢中具有生理作用。
Brown adipose tissue (BAT) is a potential therapeutic target against obesity and diabetes through thermogenesis and substrate disposal with cold exposure. The role of BAT in energy metabolism under thermoneutral conditions, however, remains controversial. We assessed the contribution of BAT to energy expenditure (EE), particularly diet-induced thermogenesis (DIT), and substrate utilization in human adults. In this cross-sectional study, BAT activity was evaluated in 21 men using 18F-fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography (18F-FDG-PET/CT) after cold exposure (19 °C). The subjects were divided into BAT-positive (n=13) and BAT-negative (n=8) groups according to the 18F-FDG-PET/CT findings. Twenty-four hour EE, DIT and respiratory quotient were measured using a whole-room indirect calorimeter at 27 °C. Body composition, blood metabolites and 24-h EE did not differ between groups. DIT (%), calculated as DIT divided by total energy intake, however, was significantly higher in the BAT-positive group (BAT-positive: 9.7±2.5%, BAT-negative: 6.5±4.0%, P=0.03). The 24-h respiratory quotient was significantly lower (P=0.03) in the BAT-positive group (0.861±0.027) than in the BAT-negative group (0.889±0.024). DIT and fat utilization were higher in BAT-positive subjects compared to BAT-negative subjects, suggesting that BAT has a physiologic role in energy metabolism.
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影响因子：
64.5
作者：
Fedorenko A;Lishko PV;Kirichok Y
通讯作者：
Kirichok Y
影响因子：
7.7
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
通讯作者：
Tsujisaki M
影响因子：
4.8
作者：
Chernogubova, E;Hutchinson, DS;Bengtsson, T
通讯作者：
Bengtsson, T
影响因子：
7.1
作者：
Eckel, RH;Hernandez, TL;Hill, JO
通讯作者：
Hill, JO
DOI：
10.1152/ajpregu.00115.2012
发表时间：
2013-01-01
影响因子：
2.8
作者：
Hibi, Masanobu;Masumoto, Ayumi;Ikemoto, Shinji
通讯作者：
Ikemoto, Shinji