Dynamic resting state functional connectivity in awake and anesthetized rodents.
Dynamic resting state functional connectivity in awake and anesthetized rodents.
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DOI：
10.1016/j.neuroimage.2014.10.013
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发表时间：
2015-01-01
期刊：
影响因子：
5.7
通讯作者：
Zhang N
中科院分区：
文献类型：
--
作者：
Liang Z;Liu X;Zhang N
自推出以来，静息态功能磁共振成像 (rsfMRI) 一直是研究正常和病理条件下功能神经网络的强大工具。在测量静息态功能连接 (RSFC) 时，大多数 rsfMRI 方法不考虑其时间变化，因此仅提供扫描时间内的平均 RSFC。最近，人们对研究人类 RSFC 的动态特性产生了浓厚的兴趣，并取得了有希望的结果。然而，我们对动物动态 RSFC 的了解仍然很少。在本研究中，我们利用单体积共激活方法系统地研究了清醒和麻醉大鼠边缘下皮层（IL）和初级体感皮层（S1）网络中 RSFC 的动态特性。我们的数据表明，IL 和 S1 网络都可以分解为几种空间上可重复但时间上变化的共激活模式 (CAP)，这表明动态 RSFC 确实是啮齿类动物的一个特征。此外，我们证明麻醉对促进认知和情感功能的神经回路的动态 RSFC 产生了深远的影响，但对感觉运动系统的影响较小。最后，我们检查了每个 CAP 的时间特征，发现各个 CAP 表现出一致的时间演化模式。总之，这些结果表明动态 RSFC 可能是脊椎动物中的普遍现象。此外，这项研究为进一步了解脑部疾病动物模型中动态RSFC的变化铺平了道路。
Since its introduction, resting-state functional magnetic resonance imaging (rsfMRI) has been a powerful tool for investigating functional neural networks in both normal and pathological conditions. When measuring resting-state functional connectivity (RSFC), most rsfMRI approaches do not consider its temporal variations and thus only provide the averaged RSFC over the scan time. Recently, there has been a surge of interest to investigate the dynamic characteristics of RSFC in humans, and promising results have been yielded. However, our knowledge regarding the dynamic RSFC in animals remains sparse. In the present study we utilized the single-volume coactivation method to systematically study the dynamic properties of RSFC within the networks of infralimbic cortex (IL) and primary somatosensory cortex (S1) in both awake and anesthetized rats. Our data showed that both IL and S1 networks could be decomposed into several spatially reproducible but temporally changing co-activation patterns (CAPs), suggesting that dynamic RSFC was indeed a characteristic feature in rodents. In addition, we demonstrated that anesthesia profoundly impacted the dynamic RSFC of neural circuits subserving cognitive and emotional functions but had less effects on sensorimotor systems. Finally, we examined the temporal characteristics of each CAP, and found that individual CAPs exhibited consistent temporal evolution patterns. Together, these results suggest that dynamic RSFC might be a general phenomenon in vertebrate animals. In addition, this study has paved the way for further understanding the alterations of dynamic RSFC in animal models of brain disorders.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
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作者：
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Stein, Elliot A.
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
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作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
3.7
作者：
Allen, Elena A.;Damaraju, Eswar;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V