Prevalence and sociodemographic correlates of antinuclear antibodies in the United States.
Prevalence and sociodemographic correlates of antinuclear antibodies in the United States.
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DOI：
10.1002/art.34380
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发表时间：
2012-07
影响因子：
--
通讯作者：
Miller, Frederick W.
中科院分区：
文献类型：
--
作者：
Satoh, Minoru;Chan, Edward K. L.;Ho, Lindsey A.;Rose, Kathryn M.;Parks, Christine G.;Cohn, Richard D.;Jusko, Todd A.;Walker, Nigel J.;Germolec, Dori R.;Whitt, Irene Z.;Crockett, Patrick W.;Pauley, Brad A.;Chan, Jason Y. F.;Ross, Steven J.;Birnbaum, Linda S.;Zeldin, Darryl C.;Miller, Frederick W.
旨在估计美国 (U.S.) 抗核抗体 (ANA) 的患病率、类型以及社会人口统计学和生物行为相关性。对 1999-2004 年国家健康和营养检查调查 (NHANES) 中的 4,754 名个体进行横断面分析。通过间接免疫荧光检测 ANA，包括 ANA 患者的细胞染色模式和通过免疫沉淀法检测的特异性自身抗体反应性。美国 12 岁及以上人群中 ANA 患病率为 13.8%（95% CI，12.2% 至 15.5%）。 ANA 随着年龄的增长而增加（P = 0.01），并且女性比男性更常见（17.8% vs. 9.6%，P < 0.001），女性与男性的比例在 40-49 岁达到峰值。非裔美国人的 ANA 患病率略高于白人（调整后的患病率比值比 [POR]，1.30；95% CI，1.00 至 1.70）。值得注意的是，与体重正常的人相比，ANA 在超重和肥胖（调整后的 POR，0.74；95% CI，0.59 至 0.94）个体中较少见。与教育、家庭收入、饮酒、吸烟史、可替宁或 C 反应蛋白的血清水平没有显着相关性。在 ANA 阳性个体中，84.6% 出现细胞核模式，21.8% 出现细胞质模式，6.1% 出现核仁模式，最常见的特异性自身抗体是抗 Ro（3.9%）和抗 Su（2.4%）。这些发现表明，美国有超过 3200 万人患有 ANA，并且女性、老年人、非裔美国人和体重正常的人中患病率较高。这些数据将作为未来调查 ANA 患病率随时间变化的预测因素和变化的有用基线。
To estimate the prevalence, types and sociodemographic and biobehavioral correlates of antinuclear antibodies (ANA) in the United States (U.S.). Cross-sectional analysis of 4,754 individuals from the National Health and Nutrition Examination Survey (NHANES) 1999–2004. ANA by indirect immunofluorescence, including cellular staining patterns and specific autoantibody reactivities by immunoprecipitation in those with ANA. ANA prevalence in the U.S. population ages 12 years and older was 13.8% (95% CI, 12.2% to 15.5%). ANA increased with age (P = 0.01) and were more prevalent among females than males (17.8% vs. 9.6%, P < 0.001), with the female to male ratio peaking at 40–49 years of age. ANA prevalence was modestly higher in African Americans than whites (adjusted prevalence odds ratio [POR], 1.30; 95% CI, 1.00 to 1.70). Remarkably, ANA were less common in overweight and obese (adjusted POR, 0.74; 95% CI, 0.59 to 0.94) individuals than persons of normal weight. No significant associations were seen with education, family income, alcohol use, smoking history, serum levels of cotinine or C-reactive protein. In ANA-positive individuals, nuclear patterns were seen in 84.6%, cytoplasmic patterns in 21.8%, and nucleolar patterns in 6.1%, and the most common specific autoantibodies were anti-Ro (3.9%) and anti-Su (2.4%). These findings suggest that over 32 million persons in the U.S. have ANA and the prevalence is higher among females, older individuals, African Americans and those with normal weight. These data will serve as a useful baseline for future investigations of predictors and changes in ANA prevalence over time.
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