Familial vs sporadic rheumatoid arthritis (RA). A prospective study in an early RA inception cohort.
Familial vs sporadic rheumatoid arthritis (RA). A prospective study in an early RA inception cohort.
复制标题
家族性与散发性类风湿性关节炎 (RA)。
DOI：
10.1093/rheumatology/39.3.267
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发表时间：
2000
期刊：
影响因子：
5.5
通讯作者：
P. van Riel
中科院分区：
文献类型：
--
作者：
T. Radstake;P. Barrera;J. Albers;H. Swinkels;L. van de Putte;P. van Riel
目标
OBJECTIVES
To study potential differences in demographic, process and outcome variables between familial and sporadic rheumatoid arthritis (RA) in an early RA inception cohort.
METHODS
In 1998, we ascertained the familial status of all collaborative patients in a large early RA inception cohort at our department. Familial RA was defined by the presence of at least two siblings fulfilling the American College of Rheumatology criteria for RA. Baseline demographic data and prospectively recorded disease activity variables, therapies and radiological damage during the first 6 yr of disease were included in the analysis. A regression analysis was performed to assess whether familial clustering is a prognostic factor.
RESULTS
We identified 142 patients with sporadic and 36 with familial RA. The most striking difference between these groups was the larger sibship size in multicase families (8.2 +/- 2.5 vs 5. 5 +/- 2.8; P < 0.0001). Age at onset was similar in both groups, although males with familiar RA were younger at disease onset than those with sporadic RA (median 50 vs 57 yr; P=0.03). No differences were found in gender, presence of rheumatoid factor (RF), antinuclear factor and HLA-DR typing or in disease activity, interventions and outcome over 6 yr of follow-up. Early radiological damage and disease activity, but not familial history of RA were prognostic for X-ray damage.
CONCLUSION
We show that sibship size is the only relevant risk factor for familial RA. No differences in genotypic and phenotypic characteristics, disease severity or radiological damage were observed among familial and sporadic RA. Familial history of RA is not a poor prognostic factor. This prospective study confirms previous cross-sectional findings in the Dutch population.
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年龄、性别和类风湿性关节炎的家族风险。
影响因子：
5
作者：
Kwoh,CK;Venglish,C;Lynn,AH;Whitley,DM;Young,E;Chakravarti,A
通讯作者：
Chakravarti,A
DOI：
10.1093/rheumatology/xxvii.suppl_2.150
发表时间：
1988
期刊：
British journal of rheumatology
影响因子：
--
作者：
Wolfe,F;Kleinheksel,SM;Khan,MA
通讯作者：
Khan,MA
影响因子：
5
作者：
D. D. del Junco-D.;H. Luthra;J. Annegers;J. Worthington;L. Kurland
通讯作者：
D. D. del Junco-D.;H. Luthra;J. Annegers;J. Worthington;L. Kurland
HLA-DRB1 基因和类风湿性关节炎的疾病严重程度。
影响因子：
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作者：
Reveille,JD;Alarcón,GS;Fowler,SE;Pillemer,SR;Neuner,R;Clegg,DO;Mikhail,IS;Trentham,DE;Leisen,JC;Bluhm,G;Cooper,SM;Duncan,H;Tuttleman,M;Heyse,SP;Sharp,JT;Tilley,B
通讯作者：
Tilley,B
家族性类风湿关节炎中 HLA-DR4 基因型频率和性别效应。
影响因子：
--
作者：
Khan,MA;Yamashita,TS;Reynolds,TL;Wolfe,F;Khan,MK
通讯作者：
Khan,MK