Effect of Caging on Cryptosporidium parvum Proliferation in Mice.
Effect of Caging on Cryptosporidium parvum Proliferation in Mice.
复制标题
笼养对小鼠体内微小隐孢子虫增殖的影响。
DOI：
10.3390/microorganisms10061242
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发表时间：
2022-06-17
期刊：
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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作者：
隐孢子虫病是由隐孢子虫属（顶复门）中的几种原生动物引起的肠道感染。免疫抑制小鼠通常用于模拟这种感染。令人惊讶的是，对于像隐孢子虫这样的病原体，它很容易通过粪口传播，关在同一个笼子里的老鼠可以发展出截然不同的感染水平，从检测不到到致命。这项研究的动机是调查这种现象，并评估隐孢子虫病的严重程度和粪便微生物群之间的关联。为此目的，检查了隐孢子虫病的严重程度与笼养（笼养组与单独笼养组）之间的关联以及微生物群分类与感染过程之间的关联。与四只一组关在笼子里的小鼠相反，大多数单独关在笼子里的小鼠没有排泄出可检测水平的卵囊。在感染前3天和感染后1天收集的样本中，微生物群α多样性与隐孢子虫病的严重程度呈负相关，表明微生物群多样性与对隐孢子虫病的易感性之间存在因果负相关关系。小的
Cryptosporidiosis is an enteric infection caused by several protozoan species in the genus Cryptosporidium (phylum Apicomplexa). Immunosuppressed mice are commonly used to model this infection. Surprisingly, for a pathogen like Cryptosporidium parvum, which is readily transmitted fecal-orally, mice housed in the same cage can develop vastly different levels of infection, ranging from undetectable to lethal. The motivation for this study was to investigate this phenomenon and assess the association between the severity of cryptosporidiosis and the fecal microbiota. To this aim, the association between severity of cryptosporidiosis and caging (group caged vs. individually caged) and between the microbiota taxonomy and the course of the infection was examined. In contrast to mice caged in groups of four, a majority of mice caged individually did not excrete a detectable level of oocysts. Microbiota α diversity in samples collected between three days prior to infection and one day post-infection was negatively correlated with the severity of cryptosporidiosis, suggesting a causal negative relationship between microbiota diversity and susceptibility to C. parvum.
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影响因子：
4.2
作者：
Gavin, Hannah E.;Satchell, Karla J. F.
通讯作者：
Satchell, Karla J. F.
影响因子：
4.8
作者：
Berry, Alexander S. F.;Johnson, Kaylynn;Beiting, Daniel P.
通讯作者：
Beiting, Daniel P.
影响因子：
64.5
作者：
Cao L;Liu X;Lin EJ;Wang C;Choi EY;Riban V;Lin B;During MJ
通讯作者：
During MJ
影响因子：
4.5
作者：
Charania, Raheela;Wade, Brandy E.;Mead, Jan R.
通讯作者：
Mead, Jan R.
影响因子：
56.3
作者：
Checkley, William;White, A. Clinton, Jr.;Jaganath, Devon;Arrowood, Michael J.;Chalmers, Rachel M.;Chen, Xian-Ming;Fayer, Ronald;Griffiths, Jeffrey K.;Guerrant, Richard L.;Hedstrom, Lizbeth;Huston, Christopher D.;Kotloff, Karen L.;Kang, Gagandeep;Mead, Jan R.;Miller, Mark;Petri, William A., Jr.;Priest, Jeffrey W.;Roos, David S.;Striepen, Boris;Thompson, R. C. Andrew;Ward, Honorine D.;Van Voorhis, Wesley A.;Xiao, Lihua;Zhu, Guan;Houpt, Eric R.
通讯作者：
Houpt, Eric R.