A framework for human microbiome research.

A framework for human microbiome research.
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DOI:
10.1038/nature11209
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发表时间:
2012-06-13
期刊:
影响因子:
64.8
通讯作者:
White, Owen
White, Owen
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Methe, Barbara A.;Nelson, Karen E.;Pop, Mihai;Creasy, Heather H.;Giglio, Michelle G.;Huttenhower, Curtis;Gevers, Dirk;Petrosino, Joseph F.;Abubucker, Sahar;Badger, Jonathan H.;Chinwalla, Asif T.;Earl, Ashlee M.;FitzGerald, Michael G.;Fulton, Robert S.;Hallsworth-Pepin, Kymberlie;Lobos, Elizabeth A.;Madupu, Ramana;Magrini, Vincent;Martin, John C.;Mitreva, Makedonka;Muzny, Donna M.;Sodergren, Erica J.;Versalovic, James;Wollam, Aye M.;Worley, Kim C.;Wortman, Jennifer R.;Young, Sarah K.;Zeng, Qiandong;Aagaard, Kjersti M.;Abolude, Olukemi O.;Allen-Vercoe, Emma;Alm, Eric J.;Alvarado, Lucia;Andersen, Gary L.;Anderson, Scott;Appelbaum, Elizabeth;Arachchi, Harindra M.;Armitage, Gary;Arze, Cesar A.;Ayvaz, Tulin;Baker, Carl C.;Begg, Lisa;Belachew, Tsegahiwot;Bhonagiri, Veena;Bihan, Monika;Blaser, Martin J.;Bloom, Toby;Bonazzi, Vivien R.;Brooks, Paul;Buck, GregoryA.;Buhay, Christian J.;Busam, Dana A.;Campbell, Joseph L.;Canon, Shane R.;Cantarel, Brandi L.;Chain, Patrick S.;Chen, I-Min A.;Chen, Lei;Chhibba, Shaila;Chu, Ken;Ciulla, Dawn M.;Clemente, Jose C.;Clifton, Sandra W.;Conlan, Sean;Crabtree, Jonathan;Cutting, Mary A.;Davidovics, Noam J.;Davis, Catherine C.;DeSantis, Todd Z.;Deal, Carolyn;Delehaunty, Kimberley D.;Dewhisrst, Floyd E.;Deych, Elena;Ding, Yan;Dooling, David J.;Dugan, Shannon P.;Dunne, W. Michael, Jr.;Durkin, A. Scott;Edgar, Robert C.;Erlich, Rachel L.;Farmer, Candace N.;Farrell, Ruth M.;Faust, Karoline;Feldgarden, Michael;Felix, Victor M.;Fisher, Sheila;Fodor, Anthony A.;Forney, Larry;Foster, Leslie;Di Francesco, Valentina;Friedman, Jonathan;Friedrich, Dennis C.;Fronick, Catrina C.;Fulton, Lucinda L.;Gao, Hongyu;Garcia, Nathalia;Giannoukos, Georgia;Giblin, Christina;Giovanni, Maria Y.;Goldberg, Jonathan M.;Goll, Johannes;Gonzalez, Antonio;Griggs, Allison;Gujja, Sharvari;Haas, Brian J.;Hamilton, Holli A.;Harris, Emily L.;Hepburn, Theresa A.;Herter, Brandi;Hoffmann, Diane E.;Holder, Michael E.;Howarth, Clinton;Huang, Katherine H.;Huse, Susan M.;Izard, Jacques;Jansson, Janet K.;Jiang, Huaiyang;Jordan, Catherine;Joshi, Vandita;Katancik, JamesA.;Keitel, WendyA.;Kelley, Scott T.;Kells, Cristyn;Kinder-Haake, Susan;King, Nicholas B.;Knight, Rob;Knights, Dan;Kong, Heidi H.;Koren, Omry;Koren, Sergey;Kota, Karthik C.;Kovar, Christie L.;Kyrpides, Nikos C.;La Rosa, Patricio S.;Lee, Sandra L.;Lemon, Katherine P.;Lennon, Niall;Lewis, Cecil M.;Lewis, Lora;Ley, Ruth E.;Li, Kelvin;Liolios, Konstantinos;Liu, Bo;Liu, Yue;Lo, Chien-Chi;Lozupone, Catherine A.;Lunsford, R. Dwayne;Madden, Tessa;Mahurkar, Anup A.;Mannon, Peter J.;Mardis, Elaine R.;Markowitz, Victor M.;Mavrommatis, Konstantinos;McCorrison, Jamison M.;McDonald, Daniel;McEwen, Jean;McGuire, Amy L.;McInnes, Pamela;Mehta, Teena;Mihindukulasuriya, Kathie A.;Miller, Jason R.;Minx, Patrick J.;Newsham, Irene;Nusbaum, Chad;O'Laughlin, Michelle;Orvis, Joshua;Pagani, Ioanna;Palaniappan, Krishna;Patel, Shital M.;Pearson, Matthew;Peterson, Jane;Podar, Mircea;Pohl, Craig;Pollard, Katherine S.;Priest, Margaret E.;Proctor, Lita M.;Qin, Xiang;Raes, Jeroen;Ravel, Jacques;Reid, Jeffrey G.;Rho, Mina;Rhodes, Rosamond;Riehle, Kevin P.;Rivera, Maria C.;Rodriguez-Mueller, Beltran;Rogers, Yu-Hui;Ross, Matthew C.;Russ, Carsten;Sanka, Ravi K.;Sankar, Pamela;Sathirapongsasuti, J. Fah;Schloss, Jeffery A.;Schloss, Patrick D.;Schmidt, Thomas M.;Scholz, Matthew;Schriml, Lynn;Schubert, Alyxandria M.;Segata, Nicola;Segre, Julia A.;Shannon, William D.;Sharp, Richard R.;Sharpton, Thomas J.;Shenoy, Narmada;Sheth, Nihar U.;Simone, Gina A.;Singh, Indresh;Smillie, Chris S.;Sobel, Jack D.;Sommer, Daniel D.;Spicer, Paul;Sutton, Granger G.;Sykes, Sean M.;Tabbaa, Diana G.;Thiagarajan, Mathangi;Tomlinson, Chad M.;Torralba, Manolito;Treangen, Todd J.;Truty, Rebecca M.;Vishnivetskaya, Tatiana A.;Walker, Jason;Wang, Lu;Wang, Zhengyuan;Ward, Doyle V.;Warren, Wesley;Watson, Mark A.;Wellington, Christopher;Wetterstrand, Kris A.;White, James R.;Wilczek-Boney, Katarzyna;Wu, Yuan Qing;Wylie, Kristine M.;Wylie, Todd;Yandava, Chandri;Ye, Liang;Ye, Yuzhen;Yooseph, Shibu;Youmans, Bonnie P.;Zhang, Lan;Zhou, Yanjiao;Zhu, Yiming;Zoloth, Laurie;Zucker, Jeremy D.;Birren, Bruce W.;Gibbs, Richard A.;Highlander, Sarah K.;Weinstock, George M.;Wilson, Richard K.;White, Owen

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各种微生物群落及其基因(微生物组)存在于整个人体中,在人类健康和疾病中发挥着重要作用。美国国立卫生研究院资助的人类微生物组计划(HMP)联盟已经建立了一个人口规模的框架,该框架促进了宏基因组方案的重大发展,产生了广泛的质量控制资源和数据,包括用于创建,处理和解释不同类型的标准化方法科学界可用的高通量宏基因组数据。在这里,我们提出了来自242名健康成年人的资源,这些人在15至18个身体部位采样多达三次,迄今为止,已经从16S rRNA基因和超过3.5 Tb的宏基因组序列中产生了5,177个微生物分类学特征。与此同时,大约800个人类相关的参考基因组已经测序。总的来说,这些数据代表了迄今为止描述人类微生物组丰度和多样性的最大资源,同时为当前和未来的研究提供了平台。
A variety of microbial communities and their genes (microbiome) exist throughout the human body, playing fundamental roles in human health and disease. The NIH funded Human Microbiome Project (HMP) Consortium has established a population-scale framework which catalyzed significant development of metagenomic protocols resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 to 18 body sites up to three times, which to date, have generated 5,177 microbial taxonomic profiles from 16S rRNA genes and over 3.5 Tb of metagenomic sequence. In parallel, approximately 800 human-associated reference genomes have been sequenced. Collectively, these data represent the largest resource to date describing the abundance and variety of the human microbiome, while providing a platform for current and future studies.
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