Estrogenic bias in T-Lymphocyte biology: Implications for cardiovascular disease.
Estrogenic bias in T-Lymphocyte biology: Implications for cardiovascular disease.
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DOI：
10.1016/j.phrs.2021.105606
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发表时间：
2021-08
影响因子：
9.3
通讯作者：
Bansal SS
中科院分区：
文献类型：
--
作者：
Rosenzweig R;Gupta S;Kumar V;Gumina RJ;Bansal SS
心血管疾病中的性别偏见已在流行病学和临床研究中得到广泛记录。尽管如此，人们对男女之间这些差异背后的精确分子机制仍知之甚少。很明显，雌二醇的生理浓度，例如绝经前女性体内的雌二醇，可以发挥男性或绝经后女性所不具备的心脏保护作用。这些心脏保护作用部分归因于雌激素受体介导的免疫系统（包括 T 细胞）的调节。雌激素受体 (ER) 广泛表达于不同的 T 细胞亚群中，已知这些亚群在心血管疾病的进展中发挥着不可或缺的作用。由于 T 细胞可以根据激活环境极化成几个不同的子集，因此它们可以具有许多不同的、可能相反的功能，并且尚不清楚雌激素受体信号传导在介导这些功能中可能发挥什么作用。不同 ER 对 T 细胞生物学的离散且经常拮抗的作用使情况变得更加复杂，这决定了许多 ER 依赖性信号通路之间的平衡。虽然雌激素对 T 细胞的多种影响与许多心血管疾病有关，但它们对其他几种（病理）生理系统的广泛影响给理解 ER 信号传导及其对免疫系统的精确影响带来了一些障碍。本综述旨在更全面地总结心血管疾病背景下雌激素受体介导的 T 细胞功能、极化和细胞因子产生的调节机制。
Gender bias in cardiovascular disease has been extensively documented in epidemiological and clinical studies. Despite this, the precise molecular mechanisms underlying these disparities between men and women are poorly understood. It is clear that physiological concentrations of estradiol, such as those present in pre-menopausal women, exert cardioprotective effects that are absent in men or in post-menopausal women. These cardioprotective effects, in part, are due to the estrogen receptor-mediated modulation of the immune system including T-cells. Estrogen receptors (ERs) are widely expressed in different T-cell subsets which are known to play an indispensable role in the progression of cardiovascular disease. Because T-cells can be polarized into several distinct subsets depending on the activation milieu, they can have many different, potentially opposing functions, and it is unclear what roles estrogen receptor signaling may play in mediating these functions. This is further complicated by the discrete and often antagonistic actions of different ERs on T-cell biology which dictate the balance between numerous ER-dependent signaling pathways. While myriad effects of estrogen in T-cells are relevant for many cardiovascular diseases, their widespread effects on several other (patho)physiological systems introduce several obstacles to understanding ER signaling and its precise effects on the immune system. This review aims to provide a more comprehensive summary of the mechanisms of estrogen receptor-mediated modulation of T-cell function, polarization, and cytokine production in the context of cardiovascular disease.
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动脉粥样硬化期间炎症的性别差异。
DOI：
10.4137/cmc.s17068
发表时间：
2014
期刊：
Clinical Medicine Insights. Cardiology
影响因子：
--
作者：
Fairweather D
通讯作者：
Fairweather D
影响因子：
20.1
作者：
Dart ML;Jankowska-Gan E;Huang G;Roenneburg DA;Keller MR;Torrealba JR;Rhoads A;Kim B;Bobadilla JL;Haynes LD;Wilkes DS;Burlingham WJ;Greenspan DS
通讯作者：
Greenspan DS
影响因子：
5.7
作者：
Cocker, M. S.;Abdel-Aty, H.;Friedrich, M. G.
通讯作者：
Friedrich, M. G.
影响因子：
82.9
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
通讯作者：
Mallat, Z
影响因子：
4.8
作者：
Eickelberg, O;Pansky, A;Roth, M
通讯作者：
Roth, M