Post-stroke depression: mechanisms, translation and therapy.
Post-stroke depression: mechanisms, translation and therapy.
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DOI：
10.1111/j.1582-4934.2012.01555.x
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发表时间：
2012-09
影响因子：
5.3
通讯作者：
Popa-Wagner A
中科院分区：
文献类型：
--
作者：
Loubinoux I;Kronenberg G;Endres M;Schumann-Bard P;Freret T;Filipkowski RK;Kaczmarek L;Popa-Wagner A
抑郁症和中风之间的相互作用非常复杂。卒中后抑郁（PSD）是卒中最常见的神经精神后果之一。抑郁症也对卒中结局产生负面影响，发病率、死亡率增加，功能恢复较差。抗抑郁药，如常用的选择性5-羟色胺再摄取抑制剂，改善中风的结果，这种效果可能远远超出抑郁症，例如，运动恢复PSD的主要生物学理论是胺假说。可以想象，缺血性病变中断了从中脑和脑干向上的投射，导致生物胺-5-羟色胺（5-HT）、多巴胺（DA）和去甲肾上腺素（NE）的生物利用度降低。乙酰胆碱也会参与其中。到目前为止，PSD的临床前和转化研究在很大程度上缺乏。合适的动物模型的实施和表征显然是深入了解中风后情绪障碍的生物学基础的主要先决条件。同样重要的是，实验模型也可能为发现新的治疗靶点铺平道路。如果我们不能预防中风，我们应该努力限制其长期后果。因此，本文综述了PSD的动物模型，并总结了潜在的潜在机制，包括基因组特征，神经递质和神经营养因子信号，海马神经发生，缺血性病变的细胞可塑性，继发性退行性变化，下丘脑-垂体-肾上腺（HPA）轴的激活和神经炎症。由于中风是一种老年人的疾病，在老年动物中破译和靶向PSD的基本机制可能会带来巨大的临床益处。
The interaction between depression and stroke is highly complex. Post-stroke depression (PSD) is among the most frequent neuropsychiatric consequences of stroke. Depression also negatively impacts stroke outcome with increased morbidity, mortality and poorer functional recovery. Antidepressants such as the commonly prescribed selective serotonin reuptake inhibitors improve stroke outcome, an effect that may extend far beyond depression, e.g., to motor recovery. The main biological theory of PSD is the amine hypothesis. Conceivably, ischaemic lesions interrupt the projections ascending from midbrain and brainstem, leading to a decreased bioavailability of the biogenic amines – serotonin (5HT), dopamine (DA) and norepinephrine (NE). Acetylcholine would also be involved. So far, preclinical and translational research on PSD is largely lacking. The implementation and characterization of suitable animal models is clearly a major prerequisite for deeper insights into the biological basis of post-stroke mood disturbances. Equally importantly, experimental models may also pave the way for the discovery of novel therapeutic targets. If we cannot prevent stroke, we shall try to limit its long-term consequences. This review therefore presents animal models of PSD and summarizes potential underlying mechanisms including genomic signatures, neurotransmitter and neurotrophin signalling, hippocampal neurogenesis, cellular plasticity in the ischaemic lesion, secondary degenerative changes, activation of the hypothalamo-pituitary-adrenal (HPA) axis and neuroinflammation. As stroke is a disease of the elderly, great clinical benefit may especially accrue from deciphering and targeting basic mechanisms underlying PSD in aged animals.
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影响因子：
3.7
作者：
Blood AJ;Iosifescu DV;Makris N;Perlis RH;Kennedy DN;Dougherty DD;Kim BW;Lee MJ;Wu S;Lee S;Calhoun J;Hodge SM;Fava M;Rosen BR;Smoller JW;Gasic GP;Breiter HC;Phenotype Genotype Project on Addiction and Mood Disorders
通讯作者：
Phenotype Genotype Project on Addiction and Mood Disorders
影响因子：
8.3
作者：
ANGELERI, F;ANGELERI, VA;NOLFE, G
通讯作者：
NOLFE, G
DOI：
10.1016/j.jaac.2009.11.005
发表时间：
2010-02-01
影响因子：
13.3
作者：
Cullen, Kathryn R.;Klimes-Dougan, Bonnie;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
影响因子：
34.7
作者：
DeRubeis, Robert J.;Siegle, Greg J.;Hollon, Steven D.
通讯作者：
Hollon, Steven D.
影响因子：
8.3
作者：
Dihné, M;Grommes, C;Block, F
通讯作者：
Block, F