Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.
Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.
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DOI：
10.1289/ehp.9906
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发表时间：
2007-10
影响因子：
10.4
通讯作者：
Graziano J
中科院分区：
文献类型：
--
作者：
Hall M;Gamble M;Slavkovich V;Liu X;Levy D;Cheng Z;van Geen A;Yunus M;Rahman M;Pilsner JR;Graziano J
在孟加拉国，数以千万计的人几十年来一直在饮用来自水的砷。As在怀孕期间被运送到胎儿的程度还没有很好地表征。因此，我们对孟加拉国Matlab分娩的101名孕妇进行了研究。采集了101对母血和脐带血，分析了总砷浓度和30对砷代谢产物。产妇尿As代谢物和血浆叶酸、钴胺素和同型半胱氨酸水平在母体脐带对也被测量。38%的家庭管井水砷浓度超过世界卫生组织10 μg/L的标准。我们观察到母体和脐带血总砷浓度之间有很强的相关性（r = 0.93, p < 0.0001）。母体和脐带血砷代谢物（n = 30）也有很强的相关性：二甲基胂酸盐（DMA） （r = 0.94, p < 0.0001）、单甲基胂酸盐（r = 0.80, p < 0.0001）、亚砷酸盐（As+3） （r = 0.80, p < 0.0001）和砷酸盐（As+5） （r = 0.89, p < 0.0001）。母体同型半胱氨酸是母体尿液、血液和脐带血中%DMA的强预测因子（β = - 6.2, p < 0.02; β = - 10.9, p < 0.04; β = - 13.7, p < 0.04）。母体叶酸与血As5+呈负相关（β = 0.56, p < 0.05），母体钴胺素与脐带血As5+呈负相关（β = - 1.2, p < 0.01）。我们得出结论，暴露于无机砷的所有代谢物发生在产前。
In Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized. We therefore conducted a study of 101 pregnant women who gave birth in Matlab, Bangladesh. Maternal and cord blood pairs were collected and concentrations of total As were analyzed for 101 pairs, and As metabolites for 30 pairs. Maternal urinary As metabolites and plasma folate, cobalamin, and homocysteine levels in maternal cord pairs were also measured. Household tube well–water As concentrations exceeded the World Health Organization guideline of 10 μg/L in 38% of the cases. We observed strong associations between maternal and cord blood concentrations of total As (r = 0.93, p < 0.0001). Maternal and cord blood arsenic metabolites (n = 30) were also strongly correlated: in dimethylarsinate (DMA) (r = 0.94, p < 0.0001), monomethylarsonate (r = 0.80, p < 0.0001), arsenite (As+3) (r = 0.80, p < 0.0001), and arsenate (As+5) (r = 0.89, p < 0.0001). Maternal homocysteine was a strong predictor of %DMA in maternal urine, maternal blood, and cord blood (β = −6.2, p < 0.02; β = −10.9, p < 0.04; and β = −13.7, p < 0.04, respectively). Maternal folate was inversely associated with maternal blood As5+ (β = 0.56, p < 0.05), and maternal cobalamin was inversely associated with cord blood As5+ (β = −1.2, p < 0.01). We conclude that exposure to all metabolites of inorganic As occurs in the prenatal period.
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影响因子：
10.4
作者：
Hopenhayn-Rich, C;Browning, SR;Gibb, H
通讯作者：
Gibb, H
影响因子：
5.4
作者：
Hopenhayn, C;Ferreccio, C;Hertz-Picciotto, I
通讯作者：
Hertz-Picciotto, I
影响因子：
4.3
作者：
Cheng, Z;Zheng, Y;van Geen, A
通讯作者：
van Geen, A
DOI：
10.1097/01.jom.0000058336.05741.e8
发表时间：
2003-03-01
影响因子：
3.2
作者：
Chen, YC;Guo, YLL;Christiani, DC
通讯作者：
Christiani, DC
DOI：
10.1016/s1470-0328(02)01307-1
发表时间：
2002-07-01
影响因子：
5.8
作者：
Guerra-Shinohara, EM;Paiva, AA;D'Almeida, V
通讯作者：
D'Almeida, V