Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy.
Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy.
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DOI：
10.1016/j.antiviral.2013.06.009
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发表时间：
2013-09
影响因子：
7.6
通讯作者：
de Lamballerie X
中科院分区：
文献类型：
--
作者：
Thiberville SD;Moyen N;Dupuis-Maguiraga L;Nougairede A;Gould EA;Roques P;de Lamballerie X
基孔肯雅热是由一种源自东非的蚊媒甲病毒引起的。在过去7年中，该病已蔓延到印度洋、亚洲和欧洲的岛屿。一种有利于伊蚊复制的突变促进了它的传播。蚊。没有疫苗或抗病毒药物可用于预防或治疗基孔肯雅热。本文提供了对该病毒和疾病的广泛回顾，包括补充表。基孔肯雅病毒（CHIKV）是蚊媒疾病基孔肯雅热的病原，基孔肯雅热是一种使人衰弱的关节炎疾病，在过去7年中，在其出现并从非洲传播到印度洋岛屿和亚洲之后，在包括新生儿在内的人类中造成了不可衡量的发病率和一些死亡率。自1950年代非洲首次报告该病存在以来，已出版了1500多份关于该病不同方面及其病原体的科学出版物。对这些出版物的分析表明，在1960年代和1970年代进行了一些研究之后，在发达国家没有本土病例的情况下，科学界的兴趣仍然很低。然而，2005年基孔肯雅热出人意料地再次出现，在印度洋及其周围形成了毁灭性的流行病。这些暴发与病毒基因组的突变有关，这些突变促进了病毒在白纹伊蚊体内的复制。从那时起，在PubMed数据库中引用了近1000篇关于基孔肯雅热的出版物。本文提供了基孔肯雅热和基孔肯雅病毒的全面综述，包括临床数据、流行病学报告、治疗方面和与体内实验室研究动物模型有关的数据。它包括所有世卫组织暴发公告的补充表、ProMED邮件警报、基因库上可获得的病毒序列，以及PubMed关于临床病例和血清阳性率研究的报告。
Chikungunya fever is caused by a mosquito-borne alphavirus originating in East Africa. During the past 7 years, the disease has spread to islands of the Indian Ocean, Asia and Europe. Its spread has been facilitated by a mutation favouring replication in the mosquito Ae. albopictus. No vaccines or antiviral drugs are available to prevent or treat chikungunya fever. This paper provides an extensive review of the virus and disease, including Supplementary Tables. Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused immeasurable morbidity and some mortality in humans, including newborn babies, following its emergence and dispersal out of Africa to the Indian Ocean islands and Asia. Since the first reports of its existence in Africa in the 1950s, more than 1500 scientific publications on the different aspects of the disease and its causative agent have been produced. Analysis of these publications shows that, following a number of studies in the 1960s and 1970s, and in the absence of autochthonous cases in developed countries, the interest of the scientific community remained low. However, in 2005 chikungunya fever unexpectedly re-emerged in the form of devastating epidemics in and around the Indian Ocean. These outbreaks were associated with mutations in the viral genome that facilitated the replication of the virus in Aedes albopictus mosquitoes. Since then, nearly 1000 publications on chikungunya fever have been referenced in the PubMed database. This article provides a comprehensive review of chikungunya fever and CHIKV, including clinical data, epidemiological reports, therapeutic aspects and data relating to animal models for in vivo laboratory studies. It includes Supplementary Tables of all WHO outbreak bulletins, ProMED Mail alerts, viral sequences available on GenBank, and PubMed reports of clinical cases and seroprevalence studies.
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DOI：
10.1016/j.berh.2011.03.005
发表时间：
2011-06-01
影响因子：
5.2
作者：
Alla, Sanae Ali Ou;Combe, Bernard
通讯作者：
Combe, Bernard
影响因子：
5.2
作者：
Allard, Pierre-Marie;Martin, Marie-Therese;Litaudon, Marc
通讯作者：
Litaudon, Marc
影响因子：
2.1
作者：
Benedict, Mark Q.;Levine, Rebecca S.;Lounibos, L. Philip
通讯作者：
Lounibos, L. Philip
DOI：
10.4269/ajtmh.1967.16.782
发表时间：
1967-01-01
影响因子：
3.3
作者：
BINN, LN;HARRISON, VR;RANDALL, R
通讯作者：
RANDALL, R
影响因子：
12.7
作者：
Brooks, Megan J.;Burtseva, Elena I.;Tannock, Gregory A.
通讯作者：
Tannock, Gregory A.