Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections.
Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections.
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DOI：
10.1111/j.1600-0897.2011.00970.x
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Fahey JV
中科院分区：
文献类型：
--
作者：
Wira CR;Patel MV;Ghosh M;Mukura L;Fahey JV
女性生殖道（FRT）的粘液表面含有一系列抗菌剂，这些抗菌剂是抵抗进入下FRT的病毒、细菌和真菌的第一道防线。一旦被认为是一个无菌室，上FRT在整个月经周期性地暴露于病原体。最近，上FRT的分泌物已被证明有助于下FRT的下游保护。在这篇综述中，我们研究了FRT分泌物中的抗菌剂，这些抗菌剂是由免疫细胞和上皮细胞在上FRT和下FRT中产生的，有助于先天保护。由于每个部位都受到生殖调节以维持生育能力，因此本文综述了月经周期期间激素平衡对先天免疫保护的贡献。如本文所述，我们实验室和其他研究表明，性激素调节先天免疫细胞在整个FRT中产生的抗菌剂。本次审查的目标是检查FRT中的抗菌药物谱以及对其进行监管的方式，以提供针对损害生殖健康并威胁妇女生命的病原体的保护。
Mucosal surfaces of the female reproductive tract (FRT) contain a spectrum of antimicrobials that provide the first line of defense against viruses, bacteria, and fungi that enter the lower FRT. Once thought to be a sterile compartment, the upper FRT is periodically exposed to pathogens throughout the menstrual cycle. More recently, secretions from the upper FRT have been shown to contribute to downstream protection in the lower FRT. In this review, we examine the antimicrobials in FRT secretions made by immune cells and epithelial cells in the upper and lower FRT that contribute to innate protection. Because each site is hormonally regulated to maintain fertility, this review focuses on the contributions of hormone balance during the menstrual cycle to innate immune protection. As presented in this review, studies from our laboratory and others demonstrate that sex hormones regulate antimicrobials produced by innate immune cells throughout the FRT. The goal of this review is to examine the spectrum of antimicrobials in the FRT and the ways in which they are regulated to provide protection against pathogens that compromise reproductive health and threaten the lives of women.
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影响因子：
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作者：
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通讯作者：
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DOI：
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