Control of surface cmposition and microstructure of nano super-hydrophilic TiO2-CuOy coatings through reactive sputtering to improve antibacterial ability, corrosion resistance, and biocompatibility
Control of surface cmposition and microstructure of nano super-hydrophilic TiO2-CuOy coatings through reactive sputtering to improve antibacterial ability, corrosion resistance, and biocompatibility
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反应溅射控制纳米超亲水TiO2-CuOy涂层的表面组成和微观结构，提高抗菌、耐腐蚀性和生物相容性
DOI：
10.1016/j.apsusc.2021.151893
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发表时间：
2021-11
影响因子：
6.7
通讯作者：
Qiang Huang
中科院分区：
文献类型：
--
作者：
Junqiang Wang;MengFan Liang;Yong Pan;Shuhong Sun;Tao Shen;Xinyuan Wei;Yan Zhu;Jinkun Liu;Qiang Huang
本文采用反应磁控溅射法在钛片上成功制备了TiO 2-CuOy抗菌超亲水纳米涂层，研究了氧含量对TiO 2-CuOy涂层的表面形貌、相组成和结构的影响，并通过分子动力学模拟了TiO 2-CuO-O2体系中TiO 2-CuO体系与O2分子的键合，得到了相应的抗菌超亲水纳米涂层。还研究了生物学和物理性质。结果表明，随着氧含量从0%增加到50%，CuO y由Cu → Cu 2 O → CuO转变，TiO 2-CuO y涂层由纳米颗粒组成，表面粗糙度随颗粒尺寸减小而呈下降趋势，这与TiO 2-CuO-O2体系的模拟结果一致。经紫外光照射后，TiO 2-CuOy涂层具有超亲水性，从而提高了涂层的抗菌性、细胞相容性和耐腐蚀性。Cu 2 O型和CuO型CuO由于具有较小的晶粒尺寸和表面粗糙度，较高的铜离子释放量，其性能优于普通纳米铜，其中TiO 2-Cu 2 O涂层对MC 3 T3-E1细胞无毒性，并显著促进细胞增殖，尤其是直接接触2 h对金黄色葡萄球菌的抑菌率达99.985%。能够预防植入早期手术部位发生感染。
In this work, the TiO2-CuOyantibacterial superhydrophilic nano-coating succeeded to be prepared on titanium sheet via the reactive magnetron sputtering, influence of oxygen content on the surface morphology, phase composition and structure of TiO2-CuOycoatings were investigated, the bonding of TiO2-CuO system to O2molecule in TiO2-CuO-O2systems was simulated through molecular dynamics, and the corresponding antibacterial, biological and physical properties were also studied. Results showed that CuOytransformed from Cu to Cu2O to CuO as the oxygen increased from 0% to50%, TiO2-CuOycoatings consisted of nano-grains, the surface roughness showed a decline trend with decreased grain size, it was consistent with the simulation result in TiO2-CuO-O2system. After being irradiated under UV, TiO2-CuOycoatings became super-hydrophilic, which obtained enhanced properties in anti-bacteria, cytocompatibility and corrosion resistance. Owing to smaller grain size and surface roughness, higher copper ions releasing amount, CuOyeither in Cu2O or CuO type performed better compared to normal nano-copper, in which TiO2-Cu2O coating was nontoxic and significantly promoted MC3T3-E1 cells proliferation, especially its antibacterial rate reached 99.985% toS.aureusunder 2 h direct contact, which was able to prevent the infections occurring at the operation site in the early implantation.
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DOI：
10.1073/pnas.1806296115
发表时间：
2018-08-07
影响因子：
11.1
作者：
Soma S;Latimer AJ;Chun H;Vicary AC;Timbalia SA;Boulet A;Rahn JJ;Chan SSL;Leary SC;Kim BE;Gitlin JD;Gohil VM
通讯作者：
Gohil VM
PIII合成的含铜钛的抗菌活性、成骨和血管生成行为
影响因子：
7
作者：
Yu Le;Jin Guodong;Ouyang Liping;Wang Donghui;Qiao Yuqin;Liu Xuanyong
通讯作者：
Liu Xuanyong
DOI：
10.1016/j.tiv.2012.12.013
发表时间：
2013-08
期刊：
Toxicology in vitro : an international journal published in association with BIBRA
影响因子：
--
作者：
Amalie Thit;H. Selck;H. Bjerregaard
通讯作者：
Amalie Thit;H. Selck;H. Bjerregaard
影响因子：
8.3
作者：
Kumar, Satendra;Narayanan, T. S. N. Sankara;Kumar, S. Saravana
通讯作者：
Kumar, S. Saravana
影响因子：
3
作者：
Liang, Mengfan;Wang, Yu;Yang, Wenlong
通讯作者：
Yang, Wenlong