The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis.
The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis.
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DOI：
10.1186/s13550-021-00831-5
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发表时间：
2021-09-06
期刊：
影响因子：
3.2
通讯作者：
Mizumura S
中科院分区：
文献类型：
--
作者：
Kido H;Kato S;Funahashi K;Shibuya K;Sasaki Y;Urita Y;Hori M;Mizumura S
正电子发射断层扫描和计算机断层扫描（PET/CT）的组合是诊断癌症的重要方式。自20世纪90年代末以来，代谢肿瘤体积（MTV）和总病变糖酵解（TLG）已被报道为PET/CT中的代谢参数，预计它们可用于诊断各种癌症和作为预后生物标志物。我们通过将这些参数与常规参数（包括最大标准化摄取值（SUVmax））进行比较，评估了这些参数在结直肠癌（CRC）预后中的潜力。我们入组了84例在2015年4月至2019年4月期间接受手术治疗CRC且无远端转移的患者。通过18 F-氟脱氧葡萄糖（FDG）-PET/CT测量SUVmax、MTV和TLG。为了找到与预后相关的最佳阈值，在基于SUVmax的固定相对和绝对阈值下测量原发性癌中的感兴趣体积（30%，40%，50%）分别为2.5、3.0和3.5）、肿瘤-肝脏标准化摄取比、TLR（1.0、1.5和2.0），SUV标准化为瘦体重，SUL（2.0、2.5和3.0）。根据病理N分期将患者分为两组后，使用非参数比较检验比较组间所有代谢参数的最佳阈值。MTV的最合适阈值为SUVmax 3.5和TLR 2.0。SUVmax值为40%的TLG显示出最显著的差异。MTV标准摄取率2.0与病理N分期显著相关。我们的研究结果表明，PET/CT上MTV TLR 2.0反映了当地CRC患者的病理N分期。
A combination of positron emission tomography and computed tomography (PET/CT) is an important modality for the diagnosis of carcinoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been reported as metabolic parameters in PET/CT since the late 1990s, and they are expected to be useful in diagnosing diverse cancers and as prognostic biomarkers. We evaluated the potential of these parameters in the prognosis of colorectal cancer (CRC) by comparing them with conventional parameters, including the maximum standardized uptake value (SUVmax). We enrolled 84 patients who underwent surgery for CRC without distal metastasis between April 2015 and April 2019. SUVmax, MTV, and TLG were measured by 18F-fluorodeoxyglucose (FDG)-PET/CT. To find an optimal threshold value related to prognosis, the volume of interest in the primary carcinoma was measured at fixed relative and absolute thresholds based on SUVmax (30%, 40%, and 50%; 2.5, 3.0, and 3.5, respectively), tumor-to-liver standardized uptake ratios, TLR (1.0, 1.5, and 2.0), and SUV normalized to lean body mass, SUL (2.0, 2.5, and 3.0). After classifying the patients into two groups according to pathological N stage, the optimal threshold values of all metabolic parameters were compared between groups using a non-parametric comparison test. The most suitable thresholds for MTV were a SUVmax of 3.5 and a TLR 2.0. TLG with a SUVmax value of 40% showed the most significant difference. The MTV standard uptake ratio of 2.0 was significantly associated with pathological N stage. Our results suggest that an MTV TLR 2.0 on PET/CT reflects pathological N stage in local patients with CRC.
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DOI：
10.1007/s002590100563
发表时间：
2001-09-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Hain, SF;Curran, KM;Maisey, MN
通讯作者：
Maisey, MN
DOI：
10.1007/s00259-014-2903-7
发表时间：
2015-02-01
影响因子：
9.1
作者：
Im, Hyung-Jun;Pak, Kyoungjune;Lee, Dong Soo
通讯作者：
Lee, Dong Soo
影响因子：
19.7
作者：
Filippone, A;Ambrosini, R;Bonomo, L
通讯作者：
Bonomo, L
影响因子：
10.6
作者：
Suzuki, Yoshiyuki;Okabayashi, Koji;Kitagawa, Yuko
通讯作者：
Kitagawa, Yuko
影响因子：
3.3
作者：
Chen, Shang-Wen;Chen, William Tzu-Liang;Kao, Chia-Hung
通讯作者：
Kao, Chia-Hung