Postsynaptic Complex Spike Bursting Enables the Induction of LTP by Theta Frequency Synaptic Stimulation
Postsynaptic Complex Spike Bursting Enables the Induction of LTP by Theta Frequency Synaptic Stimulation
复制标题
突触后复合尖峰爆发能够通过 Theta 频率突触刺激诱导 LTP
作者：
Mark J. Thomas;A. M. Watabe;T. Moody;M. Makhinson;T. O’Dell
长时程增强（Long-term potentiation，LTP）是海马CA 1区兴奋性突触的突触前和突触后同步活动所引起的突触传递的持续增强，可能参与某些形式的学习和记忆。虽然动作电位反向传播到海马锥体细胞的树突提供了足够的突触后活动，以诱导LTP在一些体外条件下，它是不知道是否可以诱导LTP的模式突触后动作电位放电发生在这些细胞在体内。在这里，我们报告的特征在体内模式的动作电位产生在CA 1锥体细胞称为复杂的棘波爆发，使诱导LTP在θ频率突触刺激在CA 1区的海马脑片cathedin体外培养。我们的研究结果表明，复杂的棘波爆发可能有一个重要的作用，在学习和记忆的形成，可能是通过产生一个高度敏感的突触后状态，在此期间，即使是低频率的突触前活动可以诱导LTP的突触过程。
Long-term potentiation (LTP), a persistent enhancement of synaptic transmission that may be involved in some forms of learning and memory, is induced at excitatory synapses in the CA1 region of the hippocampus by coincident presynaptic and postsynaptic activity. Although action potentials back-propagating into dendrites of hippocampal pyramidal cells provide sufficient postsynaptic activity to induce LTP under somein vitro conditions, it is not known whether LTP can be induced by patterns of postsynaptic action potential firing that occur in these cells in vivo. Here we report that a characteristic in vivo pattern of action potential generation in CA1 pyramidal cells known as the complex spike burst enables the induction of LTP during theta frequency synaptic stimulation in the CA1 region of hippocampal slices maintainedin vitro. Our results suggest that complex spike bursting may have an important role in synaptic processes involved in learning and memory formation, perhaps by producing a highly sensitive postsynaptic state during which even low frequencies of presynaptic activity can induce LTP.
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影响因子：
56.9
作者：
MAGEE, JC;JOHNSTON, D
通讯作者：
JOHNSTON, D
DOI：
10.1073/pnas.93.18.9921
发表时间：
1996-09-03
影响因子：
11.1
作者：
Buzsaki, G;Penttonen, M;Bragin, A
通讯作者：
Bragin, A
影响因子：
2
作者：
T. O’Dell;E. Kandel
通讯作者：
T. O’Dell;E. Kandel
海马 CA1 锥体神经元树突中 NMDA 受体介导的活性模型。
影响因子：
2.5
作者：
Pongracz,F;Poolos,NP;Kocsis,JD;Shepherd,GM
通讯作者：
Shepherd,GM
影响因子：
56.9
作者：
HUANG, YY;COLINO, A;MALENKA, RC
通讯作者：
MALENKA, RC