Livestock-associated methicillin and multidrug resistant Staphylococcus aureus is present among industrial, not antibiotic-free livestock operation workers in North Carolina.
Livestock-associated methicillin and multidrug resistant Staphylococcus aureus is present among industrial, not antibiotic-free livestock operation workers in North Carolina.
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DOI：
10.1371/journal.pone.0067641
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Heaney CD
中科院分区：
文献类型：
--
作者：
Rinsky JL;Nadimpalli M;Wing S;Hall D;Baron D;Price LB;Larsen J;Stegger M;Stewart J;Heaney CD
向食用动物施用抗生素可能会选择具有临床意义的耐药性病原体，例如耐甲氧西林金黄色葡萄球菌。在美国，研究已经调查了暴露于牲畜的个体中MRSA携带的流行率，但多重耐药S。金黄色葡萄球菌（MDRSA）的携带和与牲畜饲养与抗生素选择性压力的关系仍然不清楚。我们的目的是研究流行，抗生素敏感性，和分子特征的S。在北卡罗来纳州的工业化畜牧业经营（ILO）和无公害畜牧业经营（AFLO）工人和家庭成员中的金黄色葡萄球菌。这项横断面研究的参与者接受了采访，并提供了一个用于S。aureus分析。结果S.评估金黄色葡萄球菌分离株的抗生素敏感性、多位点序列类型和SCN基因（家畜关联的标记）的缺失。在99名ILO和105名AFLO参与者中，S.金黄色葡萄球菌鼻携带率分别为41%和40%。在劳工组织和非洲劳工组织之间。金黄色葡萄球菌携带者中，MRSA检出率分别为7%（3/41）和7%（3/42）。劳工组织41个国家中的37%，而非洲劳工组织42个国家中的19%。金阳性参与者携带MDRSA。S.金黄色葡萄球菌克隆复合体（CC）398仅在工人中观察到，在ILO中占优势（13/34），而AFLO中占优势（1/35）。金色阳性工人。仅ILO工人携带scn阴性的MRSA CC 398（2/34）和scn阴性的MDRSA CC 398（6/34），且这些分离株均对四环素耐药。尽管类似的S.在ILO和AFLO暴露个体中，与家畜相关的MRSA和MDRSA（四环素耐药，CC 398，scn阴性）仅存在于ILO暴露个体中。这些发现支持了对畜牧业生产中抗生素使用和限制的日益关注，提出了关于职业暴露于机会性和耐药病原体的可能性的问题，这在其他环境中，包括医院和社区，具有广泛的公共卫生重要性。
Administration of antibiotics to food animals may select for drug-resistant pathogens of clinical significance, such as methicillin-resistant Staphylococcus aureus (MRSA). In the United States, studies have examined prevalence of MRSA carriage among individuals exposed to livestock, but prevalence of multidrug-resistant S. aureus (MDRSA) carriage and the association with livestock raised with versus without antibiotic selective pressure remains unclear. We aimed to examine prevalence, antibiotic susceptibility, and molecular characteristics of S. aureus among industrial livestock operation (ILO) and antibiotic-free livestock operation (AFLO) workers and household members in North Carolina. Participants in this cross-sectional study were interviewed and provided a nasal swab for S. aureus analysis. Resulting S. aureus isolates were assessed for antibiotic susceptibility, multi-locus sequence type, and absence of the scn gene (a marker of livestock association). Among 99 ILO and 105 AFLO participants, S. aureus nasal carriage prevalence was 41% and 40%, respectively. Among ILO and AFLO S. aureus carriers, MRSA was detected in 7% (3/41) and 7% (3/42), respectively. Thirty seven percent of 41 ILO versus 19% of 42 AFLO S. aureus-positive participants carried MDRSA. S. aureus clonal complex (CC) 398 was observed only among workers and predominated among ILO (13/34) compared with AFLO (1/35) S. aureus-positive workers. Only ILO workers carried scn-negative MRSA CC398 (2/34) and scn-negative MDRSA CC398 (6/34), and all of these isolates were tetracycline resistant. Despite similar S. aureus and MRSA prevalence among ILO and AFLO-exposed individuals, livestock-associated MRSA and MDRSA (tetracycline-resistant, CC398, scn-negative) were only present among ILO-exposed individuals. These findings support growing concern about antibiotics use and confinement in livestock production, raising questions about the potential for occupational exposure to an opportunistic and drug-resistant pathogen, which in other settings including hospitals and the community is of broad public health importance.
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影响因子：
4.2
作者：
Casey, J. A.;Cosgrove, S. E.;Stewart, W. F.;Pollak, J.;Schwartz, B. S.
通讯作者：
Schwartz, B. S.
影响因子：
11.8
作者：
Klein E;Smith DL;Laxminarayan R
通讯作者：
Laxminarayan R
影响因子：
14.2
作者：
Kluytmans-VandenBergh, MFQ;Kluytmans, JAJW
通讯作者：
Kluytmans, JAJW
影响因子：
3.3
作者：
通讯作者：
--
影响因子：
3.2
作者：
Feil, EJ;Li, BC;Spratt, BG
通讯作者：
Spratt, BG