Enhanced psychosocial well-being following participation in a mindfulness-based stress reduction program is associated with increased natural killer cell activity.
Enhanced psychosocial well-being following participation in a mindfulness-based stress reduction program is associated with increased natural killer cell activity.
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DOI：
10.1089/acm.2009.0018
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Douglas SD
中科院分区：
文献类型：
--
作者：
Fang CY;Reibel DK;Longacre ML;Rosenzweig S;Campbell DE;Douglas SD
基于正念的减压（MBSR）计划一直被证明可以增强参与者的心理社会健康。鉴于心理社会因素和免疫功能之间的良好联系，有人假设MBSR参与者的心理社会健康状况增强与免疫活性标志物的相应变化有关。研究参与正念减压疗法后异质性患者样本的心理社会学和免疫学指标的变化。采用单组、前测后测设计。干预是在学术健康中心进行的。这项试点研究涉及24名参与者（年龄28-72岁）。入选标准为：年龄≥18岁，讲英语，无已知的自身免疫性疾病。干预是一个为期8周的MBSR计划。痛苦和生活质量（QOL）测量分别包括简明症状量表-18和医学结局调查（MOS）简表健康调查（SF-36）。免疫指标包括自然杀伤（NK）细胞的细胞溶解活性和C反应蛋白（CRP）。患者完成心理社会评估，并在基线（MBSR前）和MBSR后2周内提供血液样本。从基线到正念减压治疗后，观察到焦虑和总体痛苦以及多个QOL领域的显着改善。焦虑和总体痛苦的减少与CRP的减少有关。报告整体精神健康改善的患者也显示从MBSR前到后NK细胞溶解活性增加，而报告精神健康没有改善的患者NK细胞溶解活性没有变化。正念减压后心理健康的积极改善与NK细胞溶解活性的增加和CRP水平的降低有关。
Mindfulness-based stress reduction (MBSR) programs have consistently been shown to enhance the psychosocial well-being of participants. Given the well-established association between psychosocial factors and immunologic functioning, it has been hypothesized that enhanced psychosocial well-being among MBSR participants would be associated with corresponding changes in markers of immune activity. To examine changes in psychosocial and immunologic measures in a heterogeneous patient sample following participation in a MBSR program. A single-group, pre-test post-test design was utilized. The intervention was conducted at an academic health center. This pilot study involved twenty-four participants (aged 28–72 years). Inclusion criteria were: ≥18 years of age, English-speaking, no known autoimmune disorder. The intervention was an 8-week MBSR program. Distress and quality of life (QOL) measures included the Brief Symptom Inventory-18 and the Medical Outcomes Survey (MOS) Short-Form Health Survey (SF-36), respectively. Immunologic measures included natural killer (NK) cell cytolytic activity and C-reactive protein (CRP). Patients completed psychosocial assessments and provided a blood sample at baseline (pre-MBSR) and within 2 weeks post-MBSR. Significant improvements in anxiety and overall distress as well as across multiple domains of QOL were observed from baseline to post-MBSR. Reductions in anxiety and overall distress were associated with reductions in CRP. Patients who reported improvement in overall mental well-being also showed increased NK cytolytic activity from pre- to post-MBSR, whereas patients who reported no improvement in mental well-being showed no change in NK cytolytic activity. Positive improvement in psychological well-being following MBSR was associated with increased NK cytolytic activity and decreased levels of CRP.
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影响因子：
3.7
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