Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults.
Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults.
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DOI：
10.1371/journal.pone.0278308
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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在年轻人中，超重和高血压可能已经触发心脏重塑，正如在成年人中看到的那样，潜在地重叠非缺血性心肌病的发现。为此，在年轻超重和高血压的成年人中，我们旨在研究左心室质量（LVM）和心脏容量的变化，以及不同体重对指标化的影响。我们还旨在探讨心肌纤维化、脂肪和水肿的存在，以及细胞质量与细胞外体积（ECV）、T1和T2组织特征的变化。我们前瞻性地招募了126名无症状的受试者（51%为男性），年龄在27-41岁，进行3T心脏磁共振成像：40名对照组，40名超重，17名高血压和29名高血压超重。肌细胞质量计算为(100%-ECV) *高度2.7索引的LVM。与对照组（87±21 g）相比，超重组、高血压组和高血压超重组的绝对LVM（104±23 g, 109±27 g, 112±26 g）显著增加，且体积相似。体重超重（48±8 g/m2）与对照组（47±9 g/m2）相比，体表面积（BSA）指数导致LVM正常化，但高血压（55±9 g/m2）和高血压超重（52±9 g/m2）的LVM不正常。与正常体重相比，bsa指数过度降低了超重患者的容积（左室舒张末期容积：80±14 ml/m2对92±13 ml/m2），而身高2.7指数则没有。所有危险组的ECV（23±2%,23±2%,23±3%）均低于对照组（25±2%）（P = 0.006, P = 0.113, P = 0.039），表明心肌细胞质量增加（16.9±2.7,16.5±2.3,18.1±3.5比14.0±2.9 g/m2.7）。原生T1值相似。高血压超重组T2值降低与心率有关。总之，与对照组相比，bsa指数化掩盖了超重受试者的肥大并导致体积过度校正，因此，身高2.7指数化似乎是可取的。
In young adults, overweight and hypertension possibly already trigger cardiac remodeling as seen in mature adults, potentially overlapping non-ischemic cardiomyopathy findings. To this end, in young overweight and hypertensive adults, we aimed to investigate changes in left ventricular mass (LVM) and cardiac volumes, and the impact of different body scales for indexation. We also aimed to explore the presence of myocardial fibrosis, fat and edema, and changes in cellular mass with extracellular volume (ECV), T1 and T2 tissue characteristics. We prospectively recruited 126 asymptomatic subjects (51% male) aged 27–41 years for 3T cardiac magnetic resonance imaging: 40 controls, 40 overweight, 17 hypertensive and 29 hypertensive overweight. Myocyte mass was calculated as (100%–ECV) * height2.7-indexed LVM. Absolute LVM was significantly increased in overweight, hypertensive and hypertensive overweight groups (104 ± 23, 109 ± 27, 112 ± 26 g) versus controls (87 ± 21 g), with similar volumes. Body surface area (BSA) indexation resulted in LVM normalization in overweights (48 ± 8 g/m2) versus controls (47 ± 9 g/m2), but not in hypertensives (55 ± 9 g/m2) and hypertensive overweights (52 ± 9 g/m2). BSA-indexation overly decreased volumes in overweight versus normal-weight (LV end-diastolic volume; 80 ± 14 versus 92 ± 13 ml/m2), where height2.7-indexation did not. All risk groups had lower ECV (23 ± 2%, 23 ± 2%, 23 ± 3%) than controls (25 ± 2%) (P = 0.006, P = 0.113, P = 0.039), indicating increased myocyte mass (16.9 ± 2.7, 16.5 ± 2.3, 18.1 ± 3.5 versus 14.0 ± 2.9 g/m2.7). Native T1 values were similar. Lower T2 values in the hypertensive overweight group related to heart rate. In conclusion, BSA-indexation masks hypertrophy and causes volume overcorrection in overweight subjects compared to controls, height2.7-indexation therefore seems advisable.
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DOI：
10.1186/s12968-017-0389-8
发表时间：
2017-10-09
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
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作者：
Messroghli DR;Moon JC;Ferreira VM;Grosse-Wortmann L;He T;Kellman P;Mascherbauer J;Nezafat R;Salerno M;Schelbert EB;Taylor AJ;Thompson R;Ugander M;van Heeswijk RB;Friedrich MG
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Friedrich MG
影响因子：
2.1
作者：
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Zahediasl S
DOI：
10.1186/s12968-016-0308-4
发表时间：
2016-11-30
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
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作者：
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影响因子：
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McDiarmid, Adam K.;Swoboda, Peter P.;Plein, Sven
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Plein, Sven
影响因子：
14
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通讯作者：
Salerno, Michael