Emergence of sex-specific transcriptomes in a sexually dimorphic brain nucleus.
Emergence of sex-specific transcriptomes in a sexually dimorphic brain nucleus.
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性别特异的转录本出现在性二形脑核中。
DOI：
10.1016/j.celrep.2022.111152
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发表时间：
2022-08-02
期刊：
影响因子：
8.8
通讯作者：
V. Mello, Claudio
中科院分区：
文献类型：
--
作者：
Friedrich, Samantha R.;Nevue, Alexander A.;Andrade, Abraao L. P.;Velho, Tarciso A. F.;V. Mello, Claudio
我们提出了极端神经解剖性别差异发展背后的转录组变化。弓皮质鲁棒核（RA）是鸣禽发声运动系统的重要组成部分。在斑胸草雀中，RA最初是单形的，然后在雌性中萎缩，但在雄性中增长到7倍大。反映这种分歧，我们在这里表明，性别差异基因表达的RA扩大从数百个主要性染色体Z基因在早期发展到数千个主要的常染色体基因的时间性二型渐近线。雄性特异性发育过程包括细胞和轴突生长、突触组装和活动以及能量代谢;雌性特异性过程包括细胞极性和分化、转录抑制以及类固醇激素和免疫信号传导。转录因子结合位点分析支持女性偏向激活促凋亡调控网络。广泛的和性别特异性的转录重组RA提供了深入了解性二态神经发育的潜在驱动因素。Friedrich等人证明了鸣禽大脑中发声核RA的性二态发育的广泛转录组性别差异。他们发现性别特异性基因调控与不同的生物学过程有关，从性染色体到常染色体基因的相对信号的发育转变，以及女性偏向促凋亡调控网络的证据。
We present the transcriptomic changes underlying the development of an extreme neuroanatomical sex difference. The robust nucleus of the arcopallium (RA) is a key component of the songbird vocal motor system. In zebra finch, the RA is initially monomorphic and then atrophies in females but grows up to 7-fold larger in males. Mirroring this divergence, we show here that sex-differential gene expression in the RA expands from hundreds of predominantly sex chromosome Z genes in early development to thousands of predominantly autosomal genes by the time sexual dimorphism asymptotes. Male-specific developmental processes include cell and axonal growth, synapse assembly and activity, and energy metabolism; female-specific processes include cell polarity and differentiation, transcriptional repression, and steroid hormone and immune signaling. Transcription factor binding site analyses support female-biased activation of pro-apoptotic regulatory networks. The extensive and sex-specific transcriptomic reorganization of RA provides insights into potential drivers of sexually dimorphic neurodevelopment. Friedrich et al. demonstrate extensive transcriptomic sex differences underlying the sexually dimorphic development of vocal nucleus RA in the songbird brain. They find sex-specific gene regulation linked to distinct biological processes, developmental shifts in the relative signal from sex chromosome to autosomal genes, and evidence of female-biased pro-apoptotic regulatory networks.
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