BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.
BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.
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DOI：
10.1016/j.psychres.2009.09.008
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发表时间：
2010-07-30
影响因子：
11.3
通讯作者：
Csernansky, John G.
中科院分区：
文献类型：
--
作者：
Karnik, Meghana S.;Wang, Lei;Barch, Deanna M.;Morris, John C.;Csernansky, John G.
脑源性神经营养因子（BDNF）在包括人类在内的许多物种的海马体中高度表达。BDNF基因上的单核苷酸多态性rs6265被认为会改变该蛋白的活动依赖性分泌，并且先前的研究表明，在人类群体中，Met等位基因与海马体体积较小和记忆表现较差有关。在这项研究中，我们对154名健康人类受试者的Val66Met多态性进行了基因分型。通过高分辨率磁共振成像和高维脑图谱评估基因型对海马体体积的影响，以及通过一系列神经心理学测试评估基因型对记忆表现的影响。我们发现，在控制年龄的情况下，基因型对海马体结构没有显著影响，对记忆表现也没有显著影响。然而，年龄与全脑体积的变化和记忆任务的表现显著相关。我们得出结论，在一大群健康人类受试者中，rs6265的Met等位基因与海马体结构或记忆表现无关。
Brain Derived Neurotrophic Factor (BDNF) is highly expressed in the hippocampus of many species, including humans. The single nucleotide polymorphism rs6265 on the BDNF gene is thought to alter activity-dependant secretion of the protein, and previous research suggests that the Met allele is associated with smaller hippocampal volumes and poorer memory performance in human populations. For this study, we genotyped 154 healthy human subjects for the Val66Met polymorphism. The effects of genotype upon hippocampal volume, as assessed using high resolution magnetic resonance imaging and high dimensional brain mapping, and upon memory performance, as assessed using a battery of neuropsychological tests, were determined. We found that genotype had no significant effect on hippocampal structure, nor did it have a significant effect on memory performance, covarying for age. Age, however, was significantly related to changes in whole brain volume and performance on memory tasks. We concluded that in a large cohort of healthy human subjects, the Met allele of rs6265 is not associated with hippocampal structure or memory performance.
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影响因子：
2.6
作者：
Goldberg, Terry E.;Iudicello, Jennifer;Weinberger, Daniel R.
通讯作者：
Weinberger, Daniel R.
影响因子：
6.6
作者：
Delawalla, Zainab;Barch, Deanna M.;Csernansky, John G.
通讯作者：
Csernansky, John G.
DOI：
10.1038/npp.2008.107
发表时间：
2009-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/j.molbrainres.2005.07.008
发表时间：
2005-10-31
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
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作者：
Cheng, CY;Hong, CJ;Tsai, SJ
通讯作者：
Tsai, SJ
影响因子：
2
作者：
Bright, Peter;Buckman, Joseph;Kopelman, Michael D.
通讯作者：
Kopelman, Michael D.