Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem.
Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem.
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DOI：
10.1038/pcan.2008.19
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发表时间：
2009
影响因子：
4.8
通讯作者：
Franklin, R. B.
中科院分区：
文献类型：
--
作者：
Costello, L. C.;Franklin, R. B.
早期发现是有效治疗前列腺癌的关键，也是预防因进展为无法治疗的晚期癌症而死亡的关键。由于缓解因素，特别是良性前列腺增生（BPH），导致前列腺特异性抗原（PSA）检测的准确性低（约60%），因此迫切需要一种更可靠的生物标志物来识别早期至晚期前列腺癌和“高危”个体。为了解决这个问题，我们建议前列腺液成分的变化可以为前列腺癌的筛查提供准确可靠的生物标志物。最值得注意的是柠檬酸盐和锌的持续和显著降低，这与前列腺癌的发生和进展有关。在这篇综述中，我们提供了临床和生理基础和证据，支持实用程序的前列腺液分析作为一种有效的方法，用于筛查/检测前列腺癌，特别是早期阶段和“高危”的主题。困扰PSA检测的BPH干扰问题在潜在的前列腺液生物标志物中被消除。快速、简单、直接、准确的临床测试的潜在发展提供了额外的有利条件。迫切需要进一步探索和开发柠檬酸盐、锌和其他电解质作为前列腺液生物标志物，以解决这一关键的前列腺癌问题。
Early detection is the key to effective treatment of prostate cancer, and to the prevention of deaths due to progression to untreatable advanced stage cancer. Because of mitigating factors, especially benign prostatic hyperplasia (BPH), that result in a low accuracy (about 60%) of prostate-specific antigen (PSA) testing, there is an urgent need for a more reliable biomarker for the identification of early stage through advanced stage prostate cancer and ‘at-risk’ individuals. To address this issue we propose that changes in prostatic fluid composition could provide accurate and reliable biomarkers for the screening of prostate cancer. Most notable is the consistent and significant decrease in citrate and zinc that is associated with the development and progression of prostate cancer. In this review we provide the clinical and physiological basis and the evidence in support of the utility of prostatic fluid analysis as an effective approach for screening/detection of prostate cancer, especially early stage and ‘at-risk’ subjects. The problem of BPH interference that plagues PSA testing is eliminated in the potential prostatic fluid biomarkers. The potential development of rapid, simple, direct, accurate clinical tests provides additional advantageous conditions. Further exploration and development of citrate, zinc and other electrolytes as prostatic fluid biomarkers are urgently needed to address this critical prostate cancer issue.
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影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
影响因子：
6.6
作者：
Kline, Eric E.;Treat, Eric G.;Sillerud, Laurel O.
通讯作者：
Sillerud, Laurel O.
影响因子：
19.7
作者：
Zakian, KL;Eberhardt, S;Koutcher, JA
通讯作者：
Koutcher, JA
DOI：
10.1139/cjms52-043
发表时间：
1952-01-01
期刊：
CANADIAN JOURNAL OF MEDICAL SCIENCES
影响因子：
--
作者：
MAWSON, CA;FISCHER, MI
通讯作者：
FISCHER, MI
影响因子：
--
作者：
KAVANAGH, JP;DARBY, C;COSTELLO, CB
通讯作者：
COSTELLO, CB